Systemic Sclerosis

Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular abnormalities, immunological alterations and fibrosis of the skin and visceral organs. This complex and heterogeneous condition is associated with the highest mortality among the rheumatic diseases, but to date lacks approved disease-modifying therapies. Notable advances have been in the past 5 years in the understanding of the pathogenesis, and a number of clinical trials of therapies for SSc have shown some efficacy.  

This online collection of articles from Nature Reviews Rheumatology contains Reviews and News pieces authored by leaders in the field, covering the pathogenesis, diagnosis and management of SSc.

Fibroblasts, lungs, hands and intestines

News and Comment