Special Issue Dedicated to K. C. Nicolaou: Groundbreaking work at the frontiers of total synthesis and chemical biology

Content

Biography of Professor Nicolaou: a journey to the extremes of molecular complexity
- Nicolas Winssinger
Editorial29 Jan 2018 The Journal of Antibiotics
Professor KC Nicolaou expanded the world of synthetic organic chemistry by total synthesis and his laboratories have fostered many talented researchers
- Keiichi Ajito
Editorial29 Jan 2018 The Journal of Antibiotics
A brief history of antibiotics and select advances in their synthesis
- Kyriacos C Nicolaou
- Stephan Rigol
Review Article5 Jul 2017 The Journal of Antibiotics
Total synthesis of architecturally complex indole terpenoids: strategic and tactical evolution
- Yike Zou
- Amos B Smith III
Review Article30 Aug 2017 The Journal of Antibiotics
Chemotherapeutics overcoming nonsense mutation-associated genetic diseases: medicinal chemistry of negamycin
- Akihiro Taguchi
- Keisuke Hamada
- Yoshio Hayashi
Review Article27 Sep 2017 The Journal of Antibiotics
Challenges and discoveries in the total synthesis of complex polyketide natural products
- Ian Paterson
- Nelson Yuen Sum Lam
Review Article25 Oct 2017 The Journal of Antibiotics
Enantiospecific total synthesis of the squalene synthase inhibitors (–)-CJ-13,982 and its enantiomer from a common intermediate
- Dayna Sturgess
- Zongjia Chen
- Mark A Rizzacasa
Original Article25 Oct 2017 The Journal of Antibiotics
Total synthesis of (+)-lysergic acid
- Rentaro Kanno
- Satoshi Yokoshima
- Tohru Fukuyama
Original Article19 Jul 2017 The Journal of Antibiotics
Synthesis of deoxyelephantopin analogues
- Roman Lagoutte
- Christelle Serba
- Nicolas Winssinger
Original Article1 Nov 2017 The Journal of Antibiotics
Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition
- Shuichi Hagihara
- Kengo Hanaya
- Mitsuru Shoji
Original Article2 Aug 2017 The Journal of Antibiotics
Progress towards the total synthesis of hamigerans C and D: a direct approach to an elaborated 6-7-5 carbocyclic core
- Douglas Charles Duquette
- Thomas Jensen
- Brian Mark Stoltz
Original Article6 Sep 2017 The Journal of Antibiotics
Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety
- Hiroyasu Ando
- Aoi Kimishima
- Toshiaki Sunazuka
Original Article5 Jul 2017 The Journal of Antibiotics
Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria
- Fumiaki Nakamura
- Norio Kudo
- Nobuhiro Fusetani
Original Article29 Nov 2017 The Journal of Antibiotics
Using experimental evolution to identify druggable targets that could inhibit the evolution of antimicrobial resistance
- Heer H Mehta
- Amy G Prater
- Yousif Shamoo
Original Article20 Sep 2017 The Journal of Antibiotics
Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens
- Cuixiang Sun
- Yonghong Deng
- Xiao-Yi Xiao
Original Article26 Jul 2017 The Journal of Antibiotics
Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions
- Yoshinari Wakiyama
- Ko Kumura
- Keiichi Ajito
Original Article1 Nov 2017 The Journal of Antibiotics
Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics
- Philip C Hogan
- Chi-Li Chen
- Andrew G Myers
Original Article11 Oct 2017 The Journal of Antibiotics
A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids
- Kosuke Minagawa
- Daisuke Urabe
- Masayuki Inoue
Original Article14 Jun 2017 The Journal of Antibiotics
Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster
- Kirk A Reynolds
- Hanna Luhavaya
- Bradley S Moore
Note29 Nov 2017 The Journal of Antibiotics
Albiducins A and B, salicylaldehyde antibiotics from the ash tree-associated saprotrophic fungus Hymenoscyphus albidus
- Sandra Halecker
- Frank Surup
- Marc Stadler
Note7 Jun 2017 The Journal of Antibiotics
Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides
- Alexander R Rovira
- Yitzhak Tor
Note26 Jul 2017 The Journal of Antibiotics
Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity
- Yoshiaki Takahashi
- Eijiro Umemura
- Masakatsu Shibasaki
Communication to the Editor28 Jun 2017 The Journal of Antibiotics
Correction: Corrigendum: Total synthesis and absolute configuration of avenolide, extracellular factor in Streptomyces avermitilis
- Miho Uchida
- Satoshi Takamatsu
- Tohru Nagamitsu
Corrigendum29 Jan 2018 The Journal of Antibiotics
Correction: Corrigendum: Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology
- Hayamitsu Adachi
- Koichi Nakae
- Yoshio Nishimura
Corrigendum29 Jan 2018 The Journal of Antibiotics

Special Issue Dedicated to K. C. Nicolaou: Groundbreaking work at the frontiers of total synthesis and chemical biology

Content

Biography of Professor Nicolaou: a journey to the extremes of molecular complexity

Professor KC Nicolaou expanded the world of synthetic organic chemistry by total synthesis and his laboratories have fostered many talented researchers

A brief history of antibiotics and select advances in their synthesis

Total synthesis of architecturally complex indole terpenoids: strategic and tactical evolution

Chemotherapeutics overcoming nonsense mutation-associated genetic diseases: medicinal chemistry of negamycin

Challenges and discoveries in the total synthesis of complex polyketide natural products

Enantiospecific total synthesis of the squalene synthase inhibitors (–)-CJ-13,982 and its enantiomer from a common intermediate

Total synthesis of (+)-lysergic acid

Synthesis of deoxyelephantopin analogues

Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition

Progress towards the total synthesis of hamigerans C and D: a direct approach to an elaborated 6-7-5 carbocyclic core

Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety

Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Using experimental evolution to identify druggable targets that could inhibit the evolution of antimicrobial resistance

Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens

Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions

Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics

A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids

Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster

Albiducins A and B, salicylaldehyde antibiotics from the ash tree-associated saprotrophic fungus Hymenoscyphus albidus

Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides

Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity

Correction: Corrigendum: Total synthesis and absolute configuration of avenolide, extracellular factor in Streptomyces avermitilis

Correction: Corrigendum: Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology

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