WEB FOCUS

Reaching for regenerative medicine

In this focus

One could argue that regenerative medicine is more theory than practice: only a handful of therapies such as skin grafts and heart transplants are happening today. However, research on regeneration of mammalian tissues and organs has intensified over the past decade, with the discovery of new ways to isolate and even create stem cells that can restore function, at least in rodents. Now the challenge—a formidable one—is learning what is necessary to make it work in patients. In this web focus, we have brought together content from Nature and Nature Reports Stem Cells to highlight where we are with the basic science, and the challenge of making medicine from stem cells, whether derived from adult tissue, reprogrammed cultured cells or embryos.

Image: Courtesy of R. Passier, L. W. van Laake and C. L Mummery

Top

Regeneration in our bodies

LETTER

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors

Marco Seandel et al.

Nature 449, 346–350 (20 Sep 2007) doi:10.1038/nature06129

Abstract | Full Text | PDF | Supplementary Information

Article

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker et al.

Nature 449, 1003–1007 (25 Oct 2007) doi:10.1038/nature06196

Abstract | Full Text | PDF | Supplementary Information

LETTER

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

Maksim V. Plikus et al.

Nature 451, 340–344 (17 Jan 2008) doi:10.1038/nature06457

Abstract | Full Text | PDF | Supplementary Information

Article

DNA repair is limiting for haematopoietic stem cells during ageing

Anastasia Nijnik et al.

Nature 447, 686–690 (7 Jun 2007) doi:10.1038/nature05875

Abstract | Full Text | PDF | Supplementary Information

Top

Paths to pluripotency

News Feature

Embryonic stem cells 2.0

Bruce Goldman

Nature Reports Stem Cells (1 May 2008) doi:10.1038/stemcells.2008.67

Full Text

Article

Reprogramming of human somatic cells to pluripotency with defined factors

In-Hyun Park et al.

Nature 451, 141–146 (10 Jan 2008) doi:10.1038/nature06534

Abstract | Full Text | PDF | Supplementary Information

Making the Paper

Personalizing pluripotency

Monya Baker

Nature Reports Stem Cells (10 Jan 2008) doi:10.1038/stemcells.2007.150

Full Text

Article

Generation of germline-competent induced pluripotent stem cells

Keisuke Okita, Tomoko Ichisaka & Shinya Yamanaka

Nature 448, 313–317 (19 Jul 2007) doi:10.1038/nature05934

Abstract | Full Text | PDF | Supplementary Information

Article

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

Marius Wernig et al.

Nature 448, 318–324 (19 Jul 2007) doi:10.1038/nature05944

Abstract | Full Text | PDF | Supplementary Information

Article

Producing primate embryonic stem cells by somatic cell nuclear transfer

J. A. Byrne et al.

Nature 450, 497–502 (22 Nov 2007) doi:10.1038/nature06357

Abstract | Full Text | PDF | Supplementary Information

News Feature

Monkey embryonic stem cells cloned

Monya Baker

Nature Reports Stem Cells (21 Nov 2007) doi:10.1038/stemcells.2007.119

Full Text

Inside The Paper

Primate cells cloned by nuclear transfer

Natalie DeWitt

Nature Reports Stem Cells (21 Nov 2007) doi:10.1038/stemcells.2007.118

Full Text

Letter

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

César Cobaleda, Wolfram Jochum & Meinrad Busslinger

Nature 449, 473–477 (27 Sep 2007) doi:10.1038/nature06159

Abstract | Full Text | PDF | Supplementary Information

Top

Reaching for the Clinic

Q&A

Prepping stem cells for the clinic

Monya Baker

Nature Reports Stem Cells (10 Apr 2008) doi:10.1038/stemcells.2008.59

Full Text

Commentary

Therapeutic misconception and stem cell research

Mildred K. Cho & David Magnus

Nature Reports Stem Cells (27 Sep 2007) doi:10.1038/stemcells.2007.88

Full Text

Meeting Report

Stem-cell banking: lifeline or sub-prime?

Bryn Nelson

Nature Reports Stem Cells (13 Mar 2008) doi:10.1038/stemcells.2008.48

Full Text

NEWS

Chinese network to start trials of spinal surgery

David Cyranoski

Nature News 446, 476–477 (29 Mar 2007) doi:10.1038/446476b

Full Text | PDF

Article

Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs

Maurilio Sampaolesi et al.

Nature 444, 574–579 (30 Nov 2006) doi:10.1038/nature05282

Abstract | Full Text | PDF | Supplementary Information

NEWS AND VIEWS

Stem-cell biology: A move in the right direction

Jeffrey S. Chamberlain

Nature 444, 552–553 (30 Nov 2006) doi:10.1038/nature05406

Full Text | PDF

Letter

Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

Mayumi Ito et al.

Nature 447, 316–320 (17 May 2007) doi:10.1038/nature05766

Abstract | Full Text | PDF | Supplementary Information

News Feature

Stem cells for the heart, a new wave of clinical trials

Amy Coombs

Nature Reports Stem Cells (10 Apr 2008) doi:10.1038/stemcells.2008.55

Full Text

Top

Podcast

Listen On this week�s Nature Podcast, the latest on the UK�s controversial Embryology Bill and new research shows that Embryonic Stem Cells can self-renew without external instructions.

Top

Links

Top