Proteostasis

First aid for a damaged proteome - p869

doi:10.1038/nchembio.1684

New insights into the regulatory mechanisms of protein folding and turnover are informing the development of chemical tools and small molecules to treat proteostasis disorders.

Full Text - First aid for a damaged proteome | PDF (80.6 KB) - First aid for a damaged proteome

Proteostasis

Sculpting the proteome with small molecules - pp870 - 874

Randall W King & Daniel Finley

doi:10.1038/nchembio.1671

The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules. Here we discuss the principles that underlie the development of effective inhibitors or activators of the pathway. We emphasize insights from structural analysis and describe strategies for evaluating the selectivity of compounds.

Full Text - Sculpting the proteome with small molecules | PDF (1.63 MB) - Sculpting the proteome with small molecules

Proteostasis

Rick Morimoto - p875

Catherine Goodman

doi:10.1038/nchembio.1682

A pioneer in proteostasis is changing the way we think about organismal biology and human disease.

Full Text - Rick Morimoto | PDF (254 KB) - Rick Morimoto

Proteostasis

Energy landscapes of functional proteins are inherently risky - pp884 - 891

Anne Gershenson, Lila M Gierasch, Annalisa Pastore & Sheena E Radford

doi:10.1038/nchembio.1670

Abstract - Energy landscapes of functional proteins are inherently risky | Full Text - Energy landscapes of functional proteins are inherently risky | PDF (2.35 MB) - Energy landscapes of functional proteins are inherently risky

Proteostasis

Druggable sensors of the unfolded protein response - pp892 - 901

Dustin J Maly & Feroz R Papa

doi:10.1038/nchembio.1664

Abstract - Druggable sensors of the unfolded protein response | Full Text - Druggable sensors of the unfolded protein response | PDF (1.08 MB) - Druggable sensors of the unfolded protein response

Proteostasis

The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis - pp902 - 910

Daniel N Hebert, Lydia Lamriben, Evan T Powers & Jeffery W Kelly

doi:10.1038/nchembio.1651

Abstract - The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis | Full Text - The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis | PDF (1.81 MB) - The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis

Proteostasis

Combating neurodegenerative disease with chemical probes and model systems - pp911 - 920

Priyanka Narayan, Sepehr Ehsani & Susan Lindquist

doi:10.1038/nchembio.1663

Abstract - Combating neurodegenerative disease with chemical probes and model systems | Full Text - Combating neurodegenerative disease with chemical probes and model systems | PDF (987 KB) - Combating neurodegenerative disease with chemical probes and model systems