Cell death and immunity

How the immune system responds to dying cells can make the difference between an effective homeostatic response and one that provokes or exacerbates pathology. Over the past few years, there have been important advances in our understanding of different forms of cell death — including apoptosis, necrosis, programmed necrosis, necroptosis, pyroptosis, NETosis, immunogenic cell death and activation-induced cell death — and their consequences for immunity. This article series of Nature Reviews Immunology will feature articles that discuss the past progress and latest developments in the intersection between cell death and immunity, in the context of infection, cancer and other settings.