Mitochondria and the heart

The importance of mitochondria in cardiovascular pathophysiology and the potential of targeting mitochondrial dysfunction for clinical interventions to improve cardiac function have been increasingly recognized over the past decade. Nature Reviews Cardiology brings together a collection of the most recent articles from Nature Research journals that highlight the role of mitochondria in the heart, from mitochondrial energy production to redox signalling or mitochondrial calcium efflux, and the new opportunities for mitochondria-targeted therapies in cardiac diseases, for example, to modify the defect in energy substrate utilization associated with heart failure or to mitigate ischaemia–reperfusion injury.

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