Metastasis, the dissemination of tumour cells from a primary site leading to their progressive outgrowth at a distant organ, is ultimately what kills most patients with cancer. Yet, we are only at the cusp of our understanding of the biology of metastasis. For example, we still understand very little about why and how cancer cells migrate and invade away from the primary tumour, the mechanisms regulating cancer cell dormancy at a secondary site, the evolution and heterogeneity of metastatic lesions, why certain cancers metastasize to particular secondary organs (organotropism), and the role played by the modified microenvironment at the distant site in shaping metastatic colonization. Now, various technological developments, increased clinical sample acquisition and improved models are enabling us to overcome the gaps in our knowledge of metastasis with the hope that these conceptual advances might translate into prevention and/or treatment of metastatic disease to improve the survival of patients.

This Collection of the most recently published articles from Nature Reviews Cancer showcases the complexity of the metastatic process and the insights we have gained into the precise molecular and cellular basis of the events that facilitate cancer metastasis. This collection has been produced with exclusive support from HiberCell, Inc. The Collection content is editorially independent and the sole responsibility of Springer Nature.

This Collection is editorially independent, produced with financial support from a third party. About this content.


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