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Membrane transporters constitute a vast class of proteins whose structure and function enable selective passage of substances through cell membranes, and as such they are the target of many drugs. This Collection focuses on the mechanistic aspects of membrane carriers and current advances in the biochemical and biophysical characterizations in this field, as well presenting new research tools for membrane protein studies.
Membrane transporters are an important group of proteins in physiology and disease. Their functions make them common drug targets, but their location in the lipid bilayers poses a tremendous challenge to researchers. The current stage of development of structural biology, in addition to new research tools, has largely facilitated the acquisition of knowledge about transporters and mechanisms. This Collection presents recent studies, covering bioenergetics, structure and functional characterization of various transporters, lipids-protein interactions, and novel research tool development.