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In this cross-journal collection, we welcome a wide range of articles on the role of N6-methyladenosin in cancer including primary research articles, method-based articles, reviews, and perspectives. N6-methyladenosine (m6A) is a modified mRNA, methylated at the N6-position of adenosine, recently shown as one of the most modification of mRNA and playing an important role in stimulating tumor promotion and inhibiting tumor suppression. Thus, modification and abnormal levels of N6-Methyladenosine play an important role in cancer development and progression. For example, m6A plays a role in AML, breast cancer, ovarian cancer pancreatic and renal cell cancer. Nevertheless, our insight in the complex ways of the mechanisms of tumor-regulation is still very incomplete.