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Cellular plasticity

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The idea that cells follow a one-way trajectory to static maturity has been challenged by recent evidence that cellular identity is in fact fluid. Through the processes of dedifferentiation and transdifferentiation, mature cells can return to a stem-cell like state or convert into a different type of mature cell, following a conserved molecular program referred to as paligenosis. This plasticity enables cells to respond to intrinsic and extrinsic signals under both homeostatic and pathological conditions. Critically important in tissue repair following injury, cellular plasticity is also prevalent in cancer cells, where it contributes to tumour heterogeneity and drug resistance. This Collection invites research on the mechanisms and implications of cellular plasticity in developmental biology, regenerative medicine, cancer biology, and other fields.

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Embryonic stem cells (ESCs), coloured scanning electron micrograph (SEM).

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Submitting a paper for consideration

 

To submit your manuscript for consideration at Scientific Reports as part of this Collection, please follow the steps detailed on this page. On the first page of our online submission system, under “I’m submitting:” select the option “any other article type”. Once logged in you can submit your manuscript to a Collection by selecting “Guest Edited Collection”, under the “Choose the appropriate manuscript type” message, and clicking “Continue”. Then when filling out the manuscript information, select the "Cellular plasticity" Collection from the alphabetical list on the “Springer Nature Subject Category” tab. Authors should express their interest in the Collection in their cover letter.

Accepted papers are published on a rolling basis as soon as they are ready.

In addition to papers on Cellular plasticity, Scientific Reports welcomes all original research in the field of Cell biology. To browse our latest articles in Cell biology click here.

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