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Nature Mental Health was conceived as a means to bring together research from across the many scientific disciplines concerned with understanding the development, experience, and treatment of psychiatric disorders but also with the factors that contribute to and improve mental health and well-being. We seek to publish rigorous, high-impact, and stimulating research from across cultures and the lifespan that will contribute to better interventions and will spur insights, reduce stigma, and prompt global mental health policy change.
In advance of the formal launch in January 2023 and to showcase the potential breadth and scope of the journal, the editors of Nature Mental Health present a Collection of recent and representative mental health-themed articles from across the Nature Portfolio.
Eating disorders are prevalent and, in far too many cases, fatal. This review covers advances in genetics, neuroimaging, and animal models, and encourages a more unified science of eating disorders.
This paper identified >500 genetic loci associated with behaviors and disorders related to self-regulation, including addiction and child behavior problems. The resulting genetic risk scores predict several behavioral, medical and social outcomes.
The antidepressant response to psilocybin in individuals with treatment-resistant depression is distinct from escitalopram and depends on a global increase in brain network integration.
A global analysis across 62 studies, of which 28 were meta-analyzed, reveals an increased risk of death by suicide in patients with cancer and underscores the need for comprehensive psycho-oncological therapy during clinical routine to improve the quality of life of patients.
An open-label clinical trial of an oral absorbent that sequesters phenolic molecules in the gut shows safety and tolerability in adolescents with autism, reduces levels of gut-derived metabolites in circulation and reduces anxiety and irritability.
In this meta-analysis of 90 randomized controlled trials of youth psychological treatment, Daros et al. show that a reduction in depression and anxiety symptoms is associated with improvements in emotional regulation skills.
In a randomized controlled trial, Schleider et al. show that single-session online interventions are able to reduce depression symptoms up to three months later in adolescents.
Depressive disorders are among the leading causes of global disease burden. In this Perspective, Fried et al. argue that limited progress in understanding, predicting and treating depression despite a wealth of empirical research stems from issues in the methodological and theoretical foundations of depression measurement.
Aberrant emotional processes are evident in various mental disorders. In this Review, Lincoln et al. provide an overview of theoretical models of emotion regulation, synthesize the literature on emotion regulation in psychopathology and provide an overview of interventions that target emotion regulation.
Mental health concerns are common, but many people have difficulty accessing appropriate mental health care. In this Review, Lattie et al. present an overview of digital mental health services and provide recommendations for increasing their accessibility.
Exome sequencing analysis of 13,933 individuals with bipolar disorder finds enrichment of ultra-rare protein-truncating variants in constrained genes. Combined analysis with schizophrenia exome data identifies AKAP11 as a risk gene for both disorders.
This study investigated trajectories of depressive symptoms associated with several health conditions using a sample of over 19,000 older adults. The presence of depressive symptoms was associated with poor health prognosis and increased mortality.