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Gene therapy – the science of substituting faulty or missing genes for functioning versions to prevent genetic diseases – has been in and out of fashion for decades. Half a century ago, it was full of promise, but then a series of setbacks tempered the enthusiasm. Now, however, scientist are making genuine advances to effectively treat previously stubborn diseases. This is indicative of the field of biomedical sciences in general; long pursued innovations are finally reaching maturity with the potential of application. This Index looks at the current state of biomedical science around the world and what its renaissance might mean for patients.
A description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.
New technologies to overcome gene-therapy bottlenecks and use organoids clinically could result in fresh treatments for debilitating neurodegenerative and digestive diseases.
A conversation with Athanasios Typas, group leader in the Genome Biology Unit at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and winner of the 2022 Liliane Bettencourt Prize for Life Sciences from Fondation Bettencourt Schueller
An enzyme that modifies tumour surface glycans so that cells can break free and travel to other parts of the body is identified as crucial for ovarian cancer metastasis.
Leading surgical, bioprinting and imaging facilities at the Center for Biomedical Research in Vienna aim to bring new possibilities in cardiovascular medicine.