Special |

TRACERx

Cancers evolve at a dynamic pace to adapt to immune pressure, colonize new niches, and evade therapy. Tracking these changes can help us improve diagnosis, better tailor therapies, and forestall recurrence, but it requires intensive monitoring beyond current clinical practice. The TRACERx project, set up in 2014, aims to integrate new technologies to study cancer evolution in up to 840 lung cancer patients. From analyzing longitudinal changes in tumor DNA, to studying how these changes can be detected in blood, and expanding into the characterization of tumor immune and tissue microenvironments, several groups work collaboratively to decipher patterns and mechanisms of evolution, with the aim of applying them to improve lung cancer care.

This collection showcases the work of the TRACERx consortium, and provides further resources to explore the data and analyses published up to date. Browse the most recent publications in Nature Research, previous work, as well as Comments and community-generated content. 

Research

RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.

Article | | Nature

Comment

Research Highlights

Video