MYC
Here we present a series of specially commissioned articles that discuss the key issues and our current knowledge of MYC and cancer. Since the isolation of the MYC oncogene in the early 1980's, the concepts that try to explain how this transcription factor contributes to tumorigenesis are numerous and encompass many fields. And yet, new ideas about MYC–dependent responses and how these might be involved in tumorigenesis are still emerging as the repertoire of signalling pathways that are induced downstream of MYC activation expand. In addition, key concepts implicit in the consideration of how MYC might function as an oncogene are also likely to be relevant to other oncogenes and transcription factors, and may have therapeutic relevance.
2010
April 2010 Vol 10 No 4
MYC as a regulator of ribosome biogenesis and protein synthesis
Jan van Riggelen, Alper Yetil & Dean W. Felsher
2009
December 2009 Vol 9 No 12
The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
Tracy A. Brooks & Laurence H. Hurley
June 2009 Vol 9 No 6
Facilitating replication under stress: an oncogenic function of MYC?
Steffi Herold, Barbara Herkert & Martin Eilers
2008
December 2008 Vol 8 No 12
Reflecting on 25 years with MYC
Natalie Meyer & Linda Z. Penn
doi:10.1038/nrc2231
March 2008 Vol 8 No 3
MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
Fiona M. Watt, Michaela Frye & Salvador Aznar Benitah
doi:10.1038/nrc2328
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