Collections
Immunomodulatory drugs
- In this collection:
Immunomodulatory drugs (IMiDs), including thalidomide and its derivatives lenalidomide and pomalidomide, are currently used to treat multiple myeloma, myelodysplastic syndrome and complications from leprosy. The molecular bases for these clinical properties of IMiDs have been uncovered in research articles presented in this collection, along with related reviews and commentaries from Nature journals.
Articles in this Nature collection are freely available for the next 6 months, thanks to support from Celgene Corporation. As always, Nature Research retains sole responsibility for all editorial content.
Research Articles
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
Eric S. Fischer, Kerstin Böhm, John R. Lydeard, Haidi Yang, Michael B. Stadler et al.
Nature 512: 49-53 (2014)
doi:10.1038/nature13527
Abstract | Full Text | PDF | Supplementary information
Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Philip P Chamberlain, Antonia Lopez-Girona, Karen Miller, Gilles Carmel, Barbra Pagarigan et al.
Nature Structural & Molecular Biology 21: 803-809 (2014)
doi:10.1038/nsmb.2874
Abstract | Full Text | PDF | Supplementary information
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
Jan Krönke, Emma C. Fink, Paul W. Hollenbach, Kyle J. MacBeth, Slater N. Hurst et al.
Nature 523: 183-188 (2015)
doi:10.1038/nature14610
Abstract | Full Text | PDF | Supplementary information
© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.
