Greater awareness must be matched with steps such as better training for supervisors.
Science careers and mental health
Science’s hyper-competitive environment and its ‘publish or perish’ culture can breed anxiety and depression. Nature's latest global graduate survey, published in October 2017, showed 12% of all respondents had sought help for anxiety or depression caused by their PhD studies. And an international study published in Nature Biotechnology in March 2018 provided compelling evidence of a mental health crisis in graduate education with nearly 40% of respondents showing signs of moderate to severe depression. Our online resource aims to highlight this important issue and provides support and advice, not only to scientists struggling with poor mental health but also their colleagues, mentors, and supervisors.
Image: Sébastien Thibault
Twenty years on, Dave Reay speaks out about the depression that almost sunk his PhD, and the lifelines that saved him.
Mental illness can be devastating — but there are ways to fight it, say four researchers who have known those bleak times.
Five researchers share their stories and advice on how to maintain good mental health in the hyper-competitive environment of science.
An outpouring on Twitter highlights the acute pressures on young scientists.
The pressures of a scientific career can take their toll on people's ability to cope.
With mental illness a growing concern within graduate education, data from a new survey should prompt both academia and policy makers to consider intervention strategies.
Nature's 2017 PhD survey reveals that, despite many problems with doctoral programmes, PhD students are as committed as ever to pursuing research careers.
Researchers reflect on an initiative in New Zealand to make science more inclusive.
Displaced researchers face huge challenges making lives abroad, even if they find work.
Young people who are already struggling offline might experience greater negative effects of life online, writes Candice Odgers.
In the face of routine rejection, many scientists must learn to cope with the insidious beast that is impostor syndrome.
The rapid antidepressant activity of ketamine results from reversal of increased burst firing and synchronization in the lateral habenula in rat and mouse models of depression.
Increased expression of the potassium channel Kir4.1 on astrocytes in the lateral habenula drives neuronal bursting in rodent models of depression.
WebSchizophrenia is associated with genetic variation at the major histocompatibility complex locus; this study reveals that alleles at this locus associate with schizophrenia in proportion to their tendency to generate greater expression of complement component 4 (C4A) genes and that C4 promotes the elimination of synpases.
Salvos of neuronal activity in the brain’s lateral habenula, regulated by astrocyte cells, drive depression-like behaviours in rodents. The finding might help us to understand one antidepressant and to develop more.
The metabolism of ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and the (2R,6R)-HNK enantiomer lacks ketamine-related side effects but exerts rapid and sustained antidepressant actions in mice; these antidepressant effects are independent of NMDAR inhibition but require AMPAR activity.
A neuronal model of bipolar disorder based on induced pluripotent stem cell (iPSC) technology finds hyperactive action-potential firing and differential responsiveness to lithium in iPSC-derived neurons from patients with bipolar disorder.
Surface area expansion from 6–12 months precedes brain overgrowth in high risk infants diagnosed with autism at 24 months and cortical features in the first year predict individual diagnostic outcomes.
An X-ray structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone reveals an extended binding pocket and indicates structural features that could be used to design drugs that specifically target the D2 receptor.
The discovery in 1936 that rats respond to various damaging stimuli with a general response that involves alarm, resistance and exhaustion launched the discipline of stress research.
Alison Abbott considers a persuasive case for the link between body and mind.
Alex Haslam appraises an account of key experiments on the psychology of conflict and cooperation.
Christian Lüscher considers an alarming career from the early days of psychiatry.
Barbara A. Spellman hails an analysis of reproducibility in psychology by a champion for change.
Ananyo Bhattacharya looks back at a science-fiction touchstone on the ethics of experimental biology.
Andrew Steptoe applauds a cogent exploration of Britain's groundbreaking longitudinal birth-cohort studies.