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Prostate cancer is one of the most common cancers in men and the diagnosis alone may have profound impact on sexual function. In addition, most treatments may cause further problems including erectile dysfunction, orgasmic disturbances and changes in libido. This special issue of IJIR takes a 360 degree look at the problems, which may arise and gives concrete clinical recommendations. A must read for all those who deal with sexual function in prostate cancer patients and their partners.