Special |

Depression

Depression causes a greater burden of disability than any other condition, yet it is widely undiagnosed and untreated. In this special collection of articles, Nature asks why that burden is so great, how science is helping and where research is running aground.

Content

Mental health is gaining acceptance as a medical problem, but progress in finding treatments is being hampered by the stigma surrounding people’s everyday experiences.

Editorial | | Nature News

Cognitive behavioural therapy is the best-studied form of psychotherapy. But researchers are still struggling to understand why it works.

News Feature | | Nature News

Chronic stress can cause depression in some individuals, but leaves others untouched. Engagement of a molecular pathway controlling the production of tiny RNA snippets might help to explain the difference. See Article p.51

News & Views | | Nature

Conventional behavioural mouse models of depression are often used to study the disorder, but cannot capture the full picture of the human disease. Here, scientists present two views about the best research strategies to adopt if treatments are to be improved.

News & Views | | Nature

From the archive

Deep brain stimulation has shown promise in treating conditions such as Parkinson's disease. Now scientists are using the technology to eavesdrop on problem neural circuits.

News Feature | | Nature News

The stigma associated with mental illness discourages investment in finding cures — even though the burden of the disorders on society is immense.

Editorial | | Nature News

Research suggests that mental illnesses lie along a spectrum — but the field's latest diagnostic manual still splits them apart.

News Feature | | Nature News