Nature Cell Biology | Editorial
Organoids are cell-derived in vitro 3D organ models and allow the study of biological processes, such as cell behaviour, tissue repair and response to drugs or mutations, in an environment that mimics endogenous cell organisation and organ structures. Starting as a major technological breakthrough they are now firmly established as an essential tool in biological research and also have important implications for clinical use. A major advantage is that organoids can be grown from a limited supply of starting material, e.g. biopsies, and used for drug screening to develop individual therapies. They have further shown potential in the modelling of diseases, gene editing and transplantations and not least helped to answer many important biological questions. Efforts are underway to setup cryopreserved biobanks of human organoids as a resource for researchers and clinicians.