Across the blood-brain barrier
- Submission status
- Open
- Submission deadline
The central nerve system (CNS) plays a crucial central regulatory role in mammalian life, and the blood-brain barrier is the most selective physical barrier protecting the brain by strictly controlling the entry of specific nutrients from the periphery into the CNS and by restricting the passage of deleterious exogenous molecules (e.g., neurotoxicants) to maintain CNS homeostasis. Recently, BBB has been demonstrated as a dynamic active interface instead of a steady barrier between blood and parenchyma in the brain. However, the tight protection poses a major challenge to the therapeutic and interventional process in CNS diseases.
Aiming to facilitate brain therapeutics, this collection is open to original research across all aspects of BBB study, spanning BBB molecular and structural basis, BBB models, invasive or non-invasive approaches for enhancing delivery efficiency to the brain, and innovative translational or clinical therapeutics including chemo drugs, nucleic acids, proteins, antibodies, and cells. In particular, we welcome specific topics including but not limited to in vitro BBB models, nose-to-brain delivery, invasive brain delivery approaches, advanced materials such as extracellular vesicles, lipid vehicles, and nanoparticles, as well as effective treatments against CNS diseases such as neurodegenerative disease, aging, tumor, brain infection, neuroinflammation, stroke, epilepsy, and brain injury.
Editors
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Dr. Sharon DeMorrow, PhD, FAASLD
Division of Pharmacology and Toxicology, The University of Texas at Austin, United States
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Dr. Naveed Khan, PhD
Clinical Sciences, Istinye University, Istanbul, Turkey
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Dr. Xuefang Ren, PhD
Department of Neurosurgery, McGovern Medical School University of Texas, United States
