Multimodal selenium nanoshell-capped Au@mSiO2 nanoplatform for NIR-responsive chemo-photothermal therapy against metastatic breast cancer
Multidrug-resistant breast cancers can be overcome with a carrier containing chemotherapies and laser-active nanorods coated with selenium. Multimodal agents employing nanomaterials are attracting attention for treating multidrug-resistant cancer cells. In particular, recent studies suggest that anticancer agents combined with selenium could reduce toxic side-effects during treatment of stubborn, metastatic tumors. Jong Oh Kim at Korea’s Yeungnam University and colleagues have now added another cancer-killing technique to the co-delivery approach—using light-absorbing nanorods to heat tumor cells. The team used this laser sensitivity for on-demand release of doxorubicin drugs from a silica-nanoparticle carrier holding selenium-covered gold nanorods. Additional in vitro and mouse tests revealed that the nanomedicine enhanced tumor cell death, partly through suppressing critical signaling pathways. The absence of organ damage during animal testing bodes well for future clinical trials of selenium-based drug delivery.