Innovative Nanomaterials for Cancer Therapy

Original Articles

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  Multimodal selenium nanoshell-capped Au@mSiO₂ nanoplatform for NIR-responsive chemo-photothermal therapy against metastatic breast cancer

  A novel nanoplatform was designed by assembling nano-Se on the surface of NIR-responsive Au@mSiO₂/DOX nanoparticles for the effective treatment of metastatic breast cancer (Se@Au@mSiO₂/DOX).

  • Thiruganesh Ramasamy
  • Hima Bindu Ruttala
  • Jong Oh Kim

  ArticleOpen Access11 Apr 2018 NPG Asia Materials
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  Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

  Herein, an idea of creating MoS₂/GO nanocomposites was brought about, which were constructed to integrate the merits for both materials with additional benefits and shield the mutual weaknesses. It turned out that MoS₂/GO nanocomposites manifested beneficial multi-functionalities including favorable lung targeting, enhanced drug loading capacity, increased tumor killing efficacy and improved biosafety as well. This study would open a new path that may lead to desirable use of MoS₂/GO nanocomposites in cancer therapeutics.

  • Yun Liu
  • Jian Peng
  • Sijin Liu

  Original ArticleOpen Access5 Jan 2018 NPG Asia Materials
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  A batch-by-batch free route for the continuous production of black phosphorus nanosheets for targeted combination cancer therapy

  A batch-by-batch free route for the continuous production black phosphorus nanosheets in a single-pass gas stream was designed, and the resulting nanosheets were directly employed in targeted chemo-phototherapy upon incorporating with doxorubicin, poly-l-lysine, and hyaluronic acid.

  • Bijay Kumar Poudel
  • Jungho Hwang
  • Jeong Hoon Byeon

  ArticleOpen Access7 Aug 2018 NPG Asia Materials
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  Self-destructible polysaccharide nanocomposites with unlockable Au nanorods for high-performance photothermal therapy

  Versatile types of self-destructible polysaccharide nanocomposites with adjustable amounts of unlockable Au nanorods were fabricated for highly efficient photothermal cancer therapy systems.

  • Lizhi Song
  • Xin Zhou
  • Fu-Jian Xu

  ArticleOpen Access6 Jun 2018 NPG Asia Materials
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  The biotransformation of graphene oxide in lung fluids significantly alters its inherent properties and bioactivities toward immune cells

  GO can undergo significant physicochemical transformation in two simulated lung fluids–Gamble’s solution and artificial lysosomal fluid (ALF), as the organic acids in lung fluids cause reduction of GO. Biotransformation markedly inhibits the endocytosis of GO by scavenging macrophages. Notably, alterations in Gamble’s solution enhance the aggregation of GO in a layer-to-layer manner, resulting in GO precipitation and reduced interaction with cells, whereas changes in ALF lead to edge-to-edge aggregation of GO, enhancing the adhesion of large sheet-like GO aggregates on plasma membrane without cellular uptake.

  • Yu Qi
  • Yun Liu
  • Wei Chen

  ArticleOpen Access15 May 2018 NPG Asia Materials
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  3D printing of high-strength bioscaffolds for the synergistic treatment of bone cancer

  Fe-CaSiO₃ composite scaffolds (30CS) were designed via 3D printing technique. Firstly, 30CS scaffolds possessed high compressive strength to provide sufficient mechanical support in bone cortical defects; Secondly, a synergistic therapy of photothermal and ROS achieved enhanced tumor therapeutic effect in vitro and in vivo; Thirdly, the presence of CaSiO₃ in the composite scaffolds enforced the degradation performance and stimulated proliferation and differentiation of rBMSCs and further promoted bone forming in vivo. Such 30CS scaffolds with high compressive strength can function as versatile and efficient biomaterials for the future regeneration of cortical bone defects and therapy of bone cancer.

  • Hongshi Ma
  • Tao Li
  • Chengtie Wu

  ArticleOpen Access3 Apr 2018 NPG Asia Materials
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  Rupturing cancer cells by the expansion of functionalized stimuli-responsive hydrogels

  Using functionalized particles for treatment of cancer is advantageous because they can access remote parts of the body and is minimally invasive. However, current chemical and biological methods still face challenges. A novel approach that uses the physical force of stimuli-responsive hydrogels is introduced. Temperature-responsive hydrogels were coated with cell-adherent molecules. After attaching cancer cells on its surface and changing the temperature, the force of the expanding stimuli-responsive hydrogel ruptures the cells. Comparing to other chemical and biological methods, this physical approach may be conceptually simpler, technically easier to implement, and more general for different types of cancer cells.

  • Yan Fang
  • Jiajun Tan
  • Siowling Soh

  Original ArticleOpen Access2 Feb 2018 NPG Asia Materials
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  A 3D-printed scaffold with MoS₂ nanosheets for tumor therapy and tissue regeneration

  A bifunctional scaffold was successfully prepared by in situ growth of MoS₂ nanosheets on the 3D-printed bioceramic scaffolds via a facile hydrothermal process. The prepared scaffolds exhibit an excellent capability for both tumor therapy and tissue regeneration, offering a promising clinical strategy for effective treatment of tumor-induced tissue defects.

  • Xiaocheng Wang
  • Tao Li
  • Chengtie Wu

  Original ArticleOpen Access21 Apr 2017 NPG Asia Materials
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  Surface-engineered nanobubbles with pH-/light-responsive drug release and charge-switchable behaviors for active NIR/MR/US imaging-guided tumor therapy

  Gas filled nanobubbles are fabricated by surface-engineered progress with forming folate-mediated, gadolinium (Gd³⁺)-labelled and IR-780/5-FU loaded hollow structures. The nanobubbles progress capacity of NIR-/MR-/US-imaging in vitro. Importantly, the nanobubbles present charge-switchable behaviors when pH values changed from 7.4 to 5.0 and demonstrate pH-/light-sensitive drug release behaviors. Coupled with FA-targeting, the nanobubbles can be employed for efficient tri-modal imaging in vivo with selective tumor accumulation, long tumor retention time, and present enhanced anti-tumor activity with combined chemo-/photothermal therapy. Therefore, nanobubbles can act as excellent nanocarriers for active tumor targeting theranostics.

  • Tianliang Li
  • Jia Zhou
  • Daxiang Cui

  ArticleOpen Access7 Nov 2018 NPG Asia Materials
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  Bioinspired tumor-homing nanosystem for precise cancer therapy via reprogramming of tumor-associated macrophages

  A bioinspired nanosystem of cancer cell membrane-camouflaged SPIO@DOX-ICG nanoparticles was fabricated to realize precise cancer treatment by simultaneous chemotherapy, hyperthermia-therapy, and radiotherapy. The nanosystem achieved synergistic anticancer effects by antagonizing tumor hypoxia and reprograming the polarization of tumor associated macrophages to anti-tumor M1 phenotype, without causing toxic side effects on major organs.

  • Yanyu Huang
  • Chaoming Mei
  • Tianfeng Chen

  ArticleOpen Access12 Oct 2018 NPG Asia Materials