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Health equity is the state in which everyone has opportunity to attain full health potential and no one is disadvantaged from achieving this potential because of social position or any other socially defined circumstance. Currently, the burdens of disease and poor health and the benefits of well-being and good health are inequitably distributed both in the United States and on the global landscape. This Collection highlights the use of multidisciplinary approaches by exposure scientists and epidemiologist to understand the unequal distribution of environmental exposures, links to burden of disease, and connections to social-structural factors such as racism, racial segregation, and environmental/economic policies.