Scientific Reports

Collection 10 March 2022

Top 100 in Cancer

This collection highlights our most downloaded* cancer papers published in 2021. Featuring authors from aroud the world, these papers showcase valuable research from an international community.

*Data obtained from SN Insights which is based on Digital Science's Dimensions.

1-25

Radiotherapy for brain metastasis and long-term survival
- Kawngwoo Park
- Gi Hwan Bae
- Jaehun Jung
ArticleOpen Access13 Apr 2021 Scientific Reports
The Angelina Jolie effect: Contralateral risk-reducing mastectomy trends in patients at increased risk of breast cancer
- Narendra Nath Basu
- James Hodson
- D. Gareth Evans
ArticleOpen Access2 Feb 2021 Scientific Reports
Deep learning classification of lung cancer histology using CT images
- Tafadzwa L. Chaunzwa
- Ahmed Hosny
- Hugo J. W. L. Aerts
ArticleOpen Access9 Mar 2021 Scientific Reports
Pancancer survival analysis of cancer hallmark genes
- Ádám Nagy
- Gyöngyi Munkácsy
- Balázs Győrffy
ArticleOpen Access15 Mar 2021 Scientific Reports
Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer
- Dina M. El-Kersh
- Shahira M. Ezzat
- Mohey M. Elmazar
ArticleOpen Access29 Mar 2021 Scientific Reports
Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk
- Arun Kumar
- Mohammad Ali
- Ashok Kumar Ghosh
ArticleOpen Access27 Jan 2021 Scientific Reports
CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer
- Kelly E. Craven
- Yesim Gökmen-Polar
- Sunil S. Badve
ArticleOpen Access25 Feb 2021 Scientific Reports
The incidence and clinical analysis of non-melanoma skin cancer
- Magdalena Ciążyńska
- Grażyna Kamińska-Winciorek
- Aleksandra Lesiak
ArticleOpen Access22 Feb 2021 Scientific Reports
Real-world outcomes versus clinical trial results of immunotherapy in stage IV non-small cell lung cancer (NSCLC) in the Netherlands
- Christine M. Cramer-van der Welle
- Marjon V. Verschueren
- The Santeon NSCLC Study Group
ArticleOpen Access18 Mar 2021 Scientific Reports
Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas
- Louis Chonco
- Tomás Landete-Castillejos
- Tomás Segura
ArticleOpen Access8 Jan 2021 Scientific Reports
Risk of cancer development in patients with keloids
- Ying-Yi Lu
- Hung-Pin Tu
- Chih-Hung Lee
ArticleOpen Access30 Apr 2021 Scientific Reports
Neutrophil to lymphocyte ratio influences impact of steroids on efficacy of immune checkpoint inhibitors in lung cancer brain metastases
- Adam Lauko
- Bicky Thapa
- Manmeet S. Ahluwalia
ArticleOpen Access5 Apr 2021 Scientific Reports
Prediction of survival in patients with advanced, refractory colorectal cancer in treatment with trifluridine/tipiracil: real-world vs clinical trial data
- Ana Fernández Montes
- Alberto Carmona-Bayonas
- Teresa Garcia García
ArticleOpen Access12 Jul 2021 Scientific Reports
Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer
- Shao-Yuan Chen
- Koichi Tsuneyama
- Shih-Ming Huang
ArticleOpen Access8 Jun 2021 Scientific Reports
Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type
- Michał Piotr Budzik
- Marta Magdalena Fudalej
- Anna Maria Badowska-Kozakiewicz
ArticleOpen Access11 Mar 2021 Scientific Reports
Copper-67 radioimmunotheranostics for simultaneous immunotherapy and immuno-SPECT
- Guiyang Hao
- Tara Mastren
- Xiankai Sun
ArticleOpen Access11 Feb 2021 Scientific Reports
Associations between the gut microbiome and fatigue in cancer patients
- Joud Hajjar
- Tito Mendoza
- Aung Naing
ArticleOpen Access12 Mar 2021 Scientific Reports
cGAS–STING cytosolic DNA sensing pathway is suppressed by JAK2-STAT3 in tumor cells
- Manuel Adrian Suter
- Nikki Y. Tan
- Y. L. Zhang
ArticleOpen Access31 Mar 2021 Scientific Reports
Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray
- Yuya Higashi
- Kotaro Matsumoto
- Fuyuhiko Tamanoi
ArticleOpen Access14 Jul 2021 Scientific Reports
COVID-19 engages clinical markers for the management of cancer and cancer-relevant regulators of cell proliferation, death, migration, and immune response
- Serhiy Souchelnytskyi
- Andriy Nera
- Nazariy Souchelnytskyi
ArticleOpen Access4 Mar 2021 Scientific Reports
High-dose methotrexate-based regimens and post-remission consolidation for treatment of newly diagnosed primary CNS lymphoma: meta-analysis of clinical trials
- Junyao Yu
- Huaping Du
- Haowen Xiao
ArticleOpen Access22 Jan 2021 Scientific Reports
Sensitivity, specificity, and accuracy of a liquid biopsy approach utilizing molecular amplification pools
- Jessica Garcia
- Nick Kamps-Hughes
- Cristian Ionescu-Zanetti
ArticleOpen Access24 May 2021 Scientific Reports
A survival analysis of surgically treated incidental low-grade glioma patients
- Lingcheng Zeng
- Qi Mei
- Jian Chen
ArticleOpen Access19 Apr 2021 Scientific Reports
Integrated multi-omics analysis of ovarian cancer using variational autoencoders
- Muta Tah Hira
- M. A. Razzaque
- Mosharraf Sarker
ArticleOpen Access18 Mar 2021 Scientific Reports
Cell-free DNA concentration and fragment size as a biomarker for prostate cancer
- Emmalyn Chen
- Clinton L. Cario
- John S. Witte
ArticleOpen Access3 Mar 2021 Scientific Reports

26-50

Real-world outcomes of first-line pembrolizumab plus pemetrexed-carboplatin for metastatic nonsquamous NSCLC at US oncology practices
- Vamsidhar Velcheti
- Xiaohan Hu
- Thomas Burke
ArticleOpen Access28 Apr 2021 Scientific Reports
Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
- Ran Li
- Yimei Wang
- Bing Li
ArticleOpen Access18 Jan 2021 Scientific Reports
Comprehensive analysis of metastatic gastric cancer tumour cells using single-cell RNA-seq
- Bin Wang
- Yingyi Zhang
- Xianbao Zhan
ArticleOpen Access13 Jan 2021 Scientific Reports
Ex vivo culture of intact human patient derived pancreatic tumour tissue
- John Kokkinos
- George Sharbeen
- Phoebe A. Phillips
ArticleOpen Access21 Jan 2021 Scientific Reports
A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
- S. Mansoori
- M. Fryknäs
- P. Nygren
ArticleOpen Access26 Apr 2021 Scientific Reports
Palliative radiation therapy for symptomatic advance breast cancer
- Galia Jacobson
- Orit Kaidar-Person
- Merav Akiva Ben-David
ArticleOpen Access5 Mar 2021 Scientific Reports
Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy
- Dmitrii Bychkov
- Nina Linder
- Johan Lundin
ArticleOpen Access17 Feb 2021 Scientific Reports
A prostate-specific membrane antigen (PSMA)-targeted prodrug with a favorable in vivo toxicity profile
- Srikanth Boinapally
- Hye-Hyun Ahn
- Martin G. Pomper
ArticleOpen Access29 Mar 2021 Scientific Reports
Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer
- Franceska Dedeurwaerdere
- Kathleen BM Claes
- Geert Martens
ArticleOpen Access18 Jun 2021 Scientific Reports
Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
- Fengqin Shi
- Ya Li
- Yong Zhu
ArticleOpen Access28 Jan 2021 Scientific Reports
Efficacy and safety of new anti-CD20 monoclonal antibodies versus rituximab for induction therapy of CD20⁺ B-cell non-Hodgkin lymphomas: a systematic review and meta-analysis
- Chengxin Luo
- Guixian Wu
- Xi Li
ArticleOpen Access5 Feb 2021 Scientific Reports
Morphofunctional analysis of human pancreatic cancer cell lines in 2- and 3-dimensional cultures
- Fuuka Minami
- Norihiko Sasaki
- Toshiyuki Ishiwata
ArticleOpen Access24 Mar 2021 Scientific Reports
Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens
- Yukie Kashima
- Yosuke Togashi
- Toshihiko Doi
ArticleOpen Access11 Jan 2021 Scientific Reports
Polysaccharide hydrogel based 3D printed tumor models for chemotherapeutic drug screening
- Aragaw Gebeyehu
- Sunil Kumar Surapaneni
- Mandip Singh
ArticleOpen Access11 Jan 2021 Scientific Reports
PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer
- Guangsu Xun
- Wei Hu
- Bing Li
ArticleOpen Access12 Jul 2021 Scientific Reports
Co-culture model of B-cell acute lymphoblastic leukemia recapitulates a transcription signature of chemotherapy-refractory minimal residual disease
- Stephanie L. Rellick
- Gangqing Hu
- Laura F. Gibson
ArticleOpen Access4 Aug 2021 Scientific Reports
Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
- Britta Stapel
- Catharina Melzer
- Ralf Hass
ArticleOpen Access13 Jan 2021 Scientific Reports
Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach
- Yafei Wang
- Erik Brodin
- Paul Macklin
ArticleOpen Access18 Jan 2021 Scientific Reports
Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial
- Jeffrey A. How
- Amir A. Jazaeri
- Aung Naing
ArticleOpen Access11 Feb 2021 Scientific Reports
Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
- Daniel María Lubián López
- Carmen Aisha Butrón Hinojo
- Ernesto González Mesa
ArticleOpen Access21 Jan 2021 Scientific Reports
Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
- Fengju Chen
- Yiqun Zhang
- Chad J. Creighton
ArticleOpen Access28 Jan 2021 Scientific Reports
Selection and characterisation of Affimers specific for CEA recognition
- Shazana Hilda Shamsuddin
- David G. Jayne
- Paul A. Millner
ArticleOpen Access12 Jan 2021 Scientific Reports
Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China
- Jin Shi
- Daojuan Li
- Yutong He
ArticleOpen Access25 Mar 2021 Scientific Reports
Real-world data of fulvestrant as first-line treatment of postmenopausal women with estrogen receptor-positive metastatic breast cancer
- I. Blancas
- C. Olier
- M. Ruiz-Borrego
ArticleOpen Access19 Feb 2021 Scientific Reports
Classification of paediatric brain tumours by diffusion weighted imaging and machine learning
- Jan Novak
- Niloufar Zarinabad
- Andrew Peet
ArticleOpen Access4 Feb 2021 Scientific Reports

51-75

Metagenomic analysis of formalin-fixed paraffin-embedded tumor and normal mucosa reveals differences in the microbiome of colorectal cancer patients
- Gabriela Debesa-Tur
- Vicente Pérez-Brocal
- Andrés Moya
ArticleOpen Access11 Jan 2021 Scientific Reports
A novel proteomics approach to epigenetic profiling of circulating nucleosomes
- Priscilla Van den Ackerveken
- Alison Lobbens
- Marielle Herzog
ArticleOpen Access31 Mar 2021 Scientific Reports
A review and comparison of breast tumor cell nuclei segmentation performances using deep convolutional neural networks
- Andrew Lagree
- Majidreza Mohebpour
- William T. Tran
ArticleOpen Access13 Apr 2021 Scientific Reports
Comparative analysis of machine learning approaches to classify tumor mutation burden in lung adenocarcinoma using histopathology images
- Apaar Sadhwani
- Huang-Wei Chang
- Peter Cimermancic
ArticleOpen Access16 Aug 2021 Scientific Reports
Alteration of DNA mismatch repair capacity underlying the co-occurrence of non-small-cell lung cancer and nonmedullary thyroid cancer
- Shiro Fujita
- Katsuhiro Masago
ArticleOpen Access11 Feb 2021 Scientific Reports
Anticancer potential of rhizome extract and a labdane diterpenoid from Curcuma mutabilis plant endemic to Western Ghats of India
- T. Soumya
- T. Lakshmipriya
- P. R. Manish Kumar
ArticleOpen Access12 Jan 2021 Scientific Reports
Serum-derived exosomal PD-L1 expression to predict anti-PD-1 response and in patients with non-small cell lung cancer
- Yoshihisa Shimada
- Jun Matsubayashi
- Norihiko Ikeda
ArticleOpen Access9 Apr 2021 Scientific Reports
Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients
- Wei Han
- Chan Hu
- Guo-Liang Shen
ArticleOpen Access13 Jan 2021 Scientific Reports
Enhancing the landscape of colorectal cancer using targeted deep sequencing
- Chul Seung Lee
- In Hye Song
- Sung Hak Lee
ArticleOpen Access14 Apr 2021 Scientific Reports
PGMD/curcumin nanoparticles for the treatment of breast cancer
- Mankamna Kumari
- Nikita Sharma
- Surendra Nimesh
ArticleOpen Access15 Feb 2021 Scientific Reports
GATA3 somatic mutations are associated with clinicopathological features and expression profile in TCGA breast cancer patients
- Fahimeh Afzaljavan
- Ayeh Sadat Sadr
- Alireza Pasdar
ArticleOpen Access18 Jan 2021 Scientific Reports
Explainable drug sensitivity prediction through cancer pathway enrichment
- Yi-Ching Tang
- Assaf Gottlieb
ArticleOpen Access4 Feb 2021 Scientific Reports
A novel biosensor for the ultrasensitive detection of the lncRNA biomarker MALAT1 in non-small cell lung cancer
- Mei Chen
- Dongming Wu
- Ying Xu
ArticleOpen Access11 Feb 2021 Scientific Reports
Neuroendocrine prostate cancer has distinctive, non-prostatic HOX code that is represented by the loss of HOXB13 expression
- Siyuan Cheng
- Shu Yang
- Xiuping Yu
ArticleOpen Access2 Feb 2021 Scientific Reports
New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers
- Qinrong Zhang
- Qing-Bin Lu
ArticleOpen Access12 Jan 2021 Scientific Reports
Lung adenocarcinoma and lung squamous cell carcinoma cancer classification, biomarker identification, and gene expression analysis using overlapping feature selection methods
- Joe W. Chen
- Joseph Dhahbi
ArticleOpen Access25 Jun 2021 Scientific Reports
Similarities between pandemics and cancer in growth and risk models
- Lode K. J. Vandamme
- Ignace H. J. T. de Hingh
- Paulo R. F. Rocha
ArticleOpen Access11 Jan 2021 Scientific Reports
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2
- Ponsawan Netcharoensirisuk
- Carla Abrahamian
- Christian Grimm
ArticleOpen Access19 Apr 2021 Scientific Reports
Convolutional autoencoder based model HistoCAE for segmentation of viable tumor regions in liver whole-slide images
- Mousumi Roy
- Jun Kong
- Vandana Mukherjee
ArticleOpen Access8 Jan 2021 Scientific Reports
Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified
- Hiromasa Tanaka
- Yugo Hosoi
- Masaru Hori
ArticleOpen Access16 Sep 2021 Scientific Reports
CAD systems for colorectal cancer from WSI are still not ready for clinical acceptance
- Sara P. Oliveira
- Pedro C. Neto
- Jaime S. Cardoso
ArticleOpen Access13 Jul 2021 Scientific Reports
Applicability of pan-TRK immunohistochemistry for identification of NTRK fusions in lung carcinoma
- Simon Strohmeier
- Iva Brcic
- Luka Brcic
ArticleOpen Access7 May 2021 Scientific Reports
Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells
- Yuan Wang
- Huazhang Wu
- Yunli Zhao
ArticleOpen Access28 Jan 2021 Scientific Reports
Repositioning metformin and propranolol for colorectal and triple negative breast cancers treatment
- L. E. Anselmino
- M. V. Baglioni
- M. Menacho Márquez
ArticleOpen Access14 Apr 2021 Scientific Reports
Evaluation of wavelength ranges and tissue depth probed by diffuse reflectance spectroscopy for colorectal cancer detection
- Marcelo Saito Nogueira
- Siddra Maryam
- Stefan Andersson-Engels
ArticleOpen Access12 Jan 2021 Scientific Reports

76-100

C. elegans-based chemosensation strategy for the early detection of cancer metabolites in urine samples
- Enrico Lanza
- Martina Di Rocco
- Viola Folli
ArticleOpen Access24 Aug 2021 Scientific Reports
Detection of colorectal cancer in urine using DNA methylation analysis
- S. Bach
- I. Paulis
- R. D. M. Steenbergen
ArticleOpen Access27 Jan 2021 Scientific Reports
Learning deep features for dead and living breast cancer cell classification without staining
- Gisela Pattarone
- Laura Acion
- Emmanuel Iarussi
ArticleOpen Access13 May 2021 Scientific Reports
Epidemiological overview of multidimensional chromosomal and genome toxicity of cannabis exposure in congenital anomalies and cancer development
- Albert Stuart Reece
- Gary Kenneth Hulse
ArticleOpen Access6 Jul 2021 Scientific Reports
Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model
- Yoshihiro Miyazaki
- Tatsuya Oda
- Yasuyuki S. Kida
ArticleOpen Access25 Feb 2021 Scientific Reports
Loss of Parkinson’s susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis
- Chandra Lebovitz
- Nicole Wretham
- Sharon M. Gorski
ArticleOpen Access22 Jan 2021 Scientific Reports
Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
- Tadanobu Shimura
- Priyanka Sharma
- Ajay Goel
ArticleOpen Access6 Apr 2021 Scientific Reports
Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
- Sandeep Kumar Parvathareddy
- Abdul K. Siraj
- Khawla S. Al-Kuraya
ArticleOpen Access12 Feb 2021 Scientific Reports
Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer
- Ryoichi Katsube
- Kazuhiro Noma
- Toshiyoshi Fujiwara
ArticleOpen Access18 Jan 2021 Scientific Reports
Prognostic gene expression signatures of breast cancer are lacking a sensible biological meaning
- Kalifa Manjang
- Shailesh Tripathi
- Frank Emmert-Streib
ArticleOpen Access8 Jan 2021 Scientific Reports
Activity of docetaxel, carboplatin, and doxorubicin in patient-derived triple-negative breast cancer xenografts
- Miguel Martin
- Rocio Ramos-Medina
- Sara Lopez-Tarruella
ArticleOpen Access29 Mar 2021 Scientific Reports
Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia
- Orouba Almilaji
- Sally D. Parry
- Jonathon Snook
ArticleOpen Access22 Jun 2021 Scientific Reports
CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
- Simon Uzor
- Sean R. Porazinski
- Michael R. Ladomery
ArticleOpen Access12 Apr 2021 Scientific Reports
Prognostic value of prostate volume in non-muscle invasive bladder cancer
- Won Sik Ham
- Jee Soo Park
- Jongchan Kim
ArticleOpen Access22 Sep 2021 Scientific Reports
Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells
- Nobuki Matsumoto
- Miku Ebihara
- Toru Imamura
ArticleOpen Access15 Jan 2021 Scientific Reports
A prognostic model for colorectal cancer based on CEA and a 48-multiplex serum biomarker panel
- Kajsa Björkman
- Sirpa Jalkanen
- Caj Haglund
ArticleOpen Access22 Feb 2021 Scientific Reports
Breath biopsy of breast cancer using sensor array signals and machine learning analysis
- Hsiao-Yu Yang
- Yi-Chia Wang
- Chi-Hsiang Huang
ArticleOpen Access8 Jan 2021 Scientific Reports
Targeting the DNA replication stress phenotype of KRAS mutant cancer cells
- Tara Al Zubaidi
- O. H. Fiete Gehrisch
- Henning Willers
ArticleOpen Access11 Feb 2021 Scientific Reports
CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer
- Nataliia Petruk
- Sanni Tuominen
- Katri S. Selander
ArticleOpen Access16 Mar 2021 Scientific Reports
Targeting galectin-3 with a high-affinity antibody for inhibition of high-grade serous ovarian cancer and other MUC16/CA-125-expressing malignancies
- Marina Stasenko
- Evan Smith
- David R. Spriggs
ArticleOpen Access12 Feb 2021 Scientific Reports
The clinical significance of microvascular invasion in the surgical planning and postoperative sequential treatment in hepatocellular carcinoma
- Wentao Wang
- Yaxun Guo
- Peng Xiu
ArticleOpen Access28 Jan 2021 Scientific Reports
Elevated levels of mitochondrial CoQ₁₀ induce ROS-mediated apoptosis in pancreatic cancer
- Tulin Dadali
- Anne R. Diers
- Rangaprasad Sarangarajan
ArticleOpen Access11 Mar 2021 Scientific Reports
Evaluation of dose-volume histogram prediction for organ-at risk and planning target volume based on machine learning
- Sheng xiu Jiao
- Ming li Wang
- Xiao-wei Liu
ArticleOpen Access4 Feb 2021 Scientific Reports
Parvimonas micra, Peptostreptococcus stomatis, Fusobacterium nucleatum and Akkermansia muciniphila as a four-bacteria biomarker panel of colorectal cancer
- Muhammad Afiq Osman
- Hui-min Neoh
- Rahman Jamal
ArticleOpen Access3 Feb 2021 Scientific Reports
Abiraterone acetate versus bicalutamide in combination with gonadotropin releasing hormone antagonist therapy for high risk metastatic hormone sensitive prostate cancer
- Takashi Ueda
- Takumi Shiraishi
- Osamu Ukimura
ArticleOpen Access12 May 2021 Scientific Reports

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