Scientists are striving for a deeper view of development, from embryo to adult, cell-by-cell.
The realization that cells are the basic unit of all life helped to transform biology 180 years ago. Now, new technologies are allowing biologists to peer under the hood of individual cells from complex organisms one at a time. Their work is revealing cells’ histories and their dizzying diversity and could lead to new therapeutic approaches to disease.
Features and Comment
Aviv Regev is a maven of hard-core biological analyses. Now she is part of an effort to map every cell in the human body.
Analysing the DNA, RNA and protein of single cells is transforming our understanding of the immune system, say Amir Giladi and Ido Amit.
New tools for exploring the individual characteristics of cells are attracting researchers from other disciplines.
Tools and tips
Data from thousands of single cells can be tricky to analyse, but software advances are making it easier.
Biotechnologist finds that controversial HeLa cells could lead the way to precision cancer treatments.
DNA is packaged in the cell as chromatin, which folds into organized domains. Mapping of chromatin contacts in single cells sheds light on the dynamic evolution of these domains between cell divisions. See Article p.61
Single-cell Hi-C analysis in thousands of mouse embryonic stem cells shows that chromosomal compartments, topological-associated domains and long-range loops all have distinct cell-cycle dynamics.