Special |

Single-cell biology

The realization that cells are the basic unit of all life helped to transform biology 180 years ago. Now, new technologies are allowing biologists to peer under the hood of individual cells from complex organisms one at a time. Their work is revealing cells’ histories and their dizzying diversity and could lead to new therapeutic approaches to disease.

Features and Comment

Analysing the DNA, RNA and protein of single cells is transforming our understanding of the immune system, say Amir Giladi and Ido Amit.

Comment | | Nature News

Tools and tips

Research

DNA is packaged in the cell as chromatin, which folds into organized domains. Mapping of chromatin contacts in single cells sheds light on the dynamic evolution of these domains between cell divisions. See Article p.61

News & Views | | Nature