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Advances in cancer therapies including immunotherapy, chemotherapy, targeted agents, hormonal therapy, surgery, and radiation therapy have significantly improved cancer treatment and patient outcomes. However, these treatments can lead to a range of toxicities, which can significantly impact patients’ quality of life and long-term health. Understanding which patients are affected by treatment toxicity, and the reasons why, can help to inform strategies to manage adverse effects and develop novel therapies with reduced toxicities.
We invite submissions of primary research with a focus on minimizing and mitigating cancer therapy-related toxicity, and/or identifying new insights into the epidemiology and pathophysiology of both acute and late toxicities. We encourage submission of manuscripts describing the early detection, prediction, prevention, and patient-centered monitoring and management of cancer therapy-related toxicity. This includes studies evaluating the efficacy and safety of various interventions, such as supportive care measures, drug therapies, and lifestyle modifications, aimed at reducing toxicity and improving patient outcomes. We also welcome preclinical work that examines the mechanistic basis of cancer therapy-related toxicity, which may inform future mitigation approaches, or articles exploring the use of digital tools to minimize toxicity and improve management. Additionally, we are particularly eager to receive studies evaluating toxicities related to newer cancer therapeutic classes, such as cellular therapies. In addition to primary research, we welcome submissions of other article types, such as Reviews, Perspectives, and Comments that provide significant insights into the topic. All submissions will be subject to the same review process and editorial standards as regular Communications Medicine Articles.
Karthikeyan et al. use WHO pharmacovigilance data to evaluate cardiotoxicity profiles of CAR-T therapy and bispecific T-cell engagers. They find evidence of severe adverse cardiovascular events, including heart failure, in some patients treated with tisagenlecleucel.
Bryant et al. report findings of a dosimetric analysis of adapted versus non-adapted radiation therapy plans of ultracentral lung lesions treated with ablative stereotactic MRI-guided adaptive radiation therapy. The differences demonstrated help to elucidate the therapeutic window improvements of daily plan adaptation.
Cogno et al. develop and characterize a hybrid agent-based – Monte Carlo model of radiation-induced lung fibrosis in an alveolar segment. The model takes into account spatial data of the dose distribution and replicates in vivo findings for different fractionation schemes and radiation types.
Iturri, Bertho et al. analyze the effects of oxygen administration during anesthesia in conventional and FLASH proton therapy in a rat model. They demonstrate the detrimental effect of varying oxygen supply using histologic, cytometric and behavioral analysis, and highlighting the urgent need to optimize anesthesia protocols in pediatric oncology.
Yuda et al. report the development and evaluation of a novel selective MCL-1 inhibitor, ABBV-467. The compound is efficacious in preclinical models but increases in cardiac troponin are seen in a first-in-human study, suggesting potential cardiac toxicity of the drug.