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Tackling antimicrobial resistance

Antimicrobial resistance remains a global health threat, in this collection we present companies developing therapeutics to urgently fight against a range of potentially dangerous pathogens.

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Profiles

Forge Therapeutics has built a proprietary platform called MAGNET (Metalloprotein-targeting Approach to Generating New Experimental Therapeutics) to discover novel-class anti-infectives. With a development candidate to treat infections caused by high-priority Gram-negative pathogens, Forge is advancing its portfolio with partners worldwide.

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Northern Antibiotics is developing improved versions of polymyxins to help fight against resistant Gram-negative bacteria and has three parallel programs in development.

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Protein engineering company Lytica Therapeutics is pioneering the use of α-helical stapled antimicrobial peptides (StAMPs) to lyse and kill multidrug-resistant bacteria.

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The Swiss pharmaceutical company BioVersys is developing next-generation antimicrobial drugs with unique modes of action targeting a range of multidrug-resistant bacteria.

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Lysando AG’s Artilysin platform technology is producing novel antimicrobial proteins with a unique mode of action and a wide range of applications, from human and veterinary medicine to the food and cosmetics industry. Lysando is licensing the technology to companies all around the world.

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Amicrobe engineers biologics-as-materials that are applied locally in surgery and trauma to prevent and treat life-threatening infections.

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Cytophage has developed a versatile bacteriophage-based antibacterial and antiviral technology targeting human and agricultural infectious diseases. With lead programs in avian and swine bacterial infections and in COVID-19, the company is seeking to expand its partnership network.

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Biofilms are a major contributor to the global challenge of antibiotic resistance. BioFilm Control is leading the way in eradicating the biofilm barrier and overcoming antibiotic resistance with compounds that have blockbuster potential.

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