Hemolytic processes in paroxysmal nocturnal hemoglobinuria and its treatment: intravascular and extravascular hemolysis

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  Paroxysmal nocturnal haemoglobinuria

  Anaemia, thrombosis and smooth muscle dystonias are manifestations of paroxysmal nocturnal haemoglobinuria, a rare but potentially life-threatening haematological disorder. Inhibition of complement activation is the treatment of choice; stem cell transplantation is recommended for patients who also develop severe bone marrow failure.

  • Anita Hill
  • Amy E. DeZern
  • Robert A. Brodsky

  Primer18 May 2017 Nature Reviews Disease Primers

• Outcomes of haploidentical haematopoietic stem cell transplantation for paroxysmal nocturnal haemoglobinuria

  • Limin Liu
  • Yanming Zhang
  • Depei Wu

  Correspondence19 Nov 2019 Bone Marrow Transplantation

• Combined intensive immunosuppression and eculizumab for aplastic anemia in the context of hemolytic paroxysmal nocturnal hemoglobinuria: a retrospective analysis

  • S Pagliuca
  • A M Risitano
  • R P De Latour

  Letter to the Editor13 Nov 2017 Bone Marrow Transplantation
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  Clonal PIGA mosaicism and dynamics in paroxysmal nocturnal hemoglobinuria

  • Michael J. Clemente
  • Bartlomiej Przychodzen
  • Jaroslaw P. Maciejewski

  Brief Communication25 Apr 2018 Leukemia
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  Unmanipulated haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in a patient with paroxysmal nocturnal hemoglobinuria and secondary aplastic anemia

  • M Sarmiento
  • P A Ramírez

  Letter to the Editor26 Oct 2015 Bone Marrow Transplantation