Special 

Human Microbiome Project, part 2

The second phase of the 10-year NIH-funded Human Microbiome Project (HMP2) has reached its fruition in the form of a collection of studies addressing the role of the microbiota in inflammatory bowel disease, the onset of type 2 diabetes and in pregnancy and preterm birth. Through the power of multi-omic technologies and clinical analyses, these studies provide the most comprehensive analysis of both the host and the microbiota to date, revealing important insights into the complex interplay between these partners and how this changes over time. The work of the HMP has generated vital resources and analytical tools that continue to fuel progress in the field, and has set a precedent for future human multi-omic studies that strive to integrate basic and clinical science.

We are pleased to present this Nature collection of commentary and research publications from across Nature journals and related publications from HMP2.

HMP resources

Human Microbiome Project portal: https://www.hmpdacc.org/

 

Recently published content related to HMP2

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients.

Hall et al. Genome Med. 2017 Nov 28;9(1):103. doi: 10.1186/s13073-017-0490-5

bioBakery: a meta'omic analysis environment.

McIver et al. Bioinformatics. 2018 Apr 1;34(7):1235-1237. doi: 10.1093/bioinformatics/btx754

Relationship between vitamin D status and the vaginal microbiome during pregnancy.

Jefferson et al.  J Perinatol. 2019 Jun;39(6):824-836. doi: 10.1038/s41372-019-0343-8

Glucotypes reveal new patterns of glucose dysregulation.

Hall et al. PLoS Biol. 2018 Jul 24;16(7):e2005143. doi: 10.1371/journal.pbio.2005143

High-frequency actionable pathogenic exome variants in an average-risk cohort.

Rego S. & Dagan-Rosenfeld O. et al. Cold Spring Harb Mol Case Stud. 2018 Dec 17;4(6). pii: a003178. doi: 10.1101/mcs.a003178.

Much ado about nothing: A qualitative study of the experiences of an average-risk population receiving results of exome sequencing.

Rego et al. J Genet Couns. 2019 Apr;28(2):428-437. doi: 10.1002/jgc4.1096