Collection |

Engineered tissues

Research on disease mechanisms will increasingly be supported by progressively more sophisticated engineered tissues serving as in vitro models of human disease.
 
This Collection is updated when relevant new content is published. Content appears in reverse chronological order.  See all Collections from Nature Biomedical Engineering.

Research

  • Nature Biomedical Engineering | Article

    Cardiac tissue engineered to enable the modulation of mechanical resistance to tissue contraction facilitates the modelling of genetic pathologies associated with the absence of a thick-filament accessory protein found in striated heart muscle.

    • Zhen Ma
    • , Nathaniel Huebsch
    • , Sangmo Koo
    • , Mohammad A. Mandegar
    • , Brian Siemons
    • , Steven Boggess
    • , Bruce R. Conklin
    • , Costas P. Grigoropoulos
    •  &  Kevin E. Healy
  • Nature Biomedical Engineering | Article

    Scale models of the human left ventricle made of tissue-engineered nanofibrous scaffolds and primary rat cardiomyocytes or human-stem-cell-derived cardiomyocytes enable the study of contractile function and the modelling of structural arrhythmia.

    • Luke A. MacQueen
    • , Sean P. Sheehy
    • , Christophe O. Chantre
    • , John F. Zimmerman
    • , Francesco S. Pasqualini
    • , Xujie Liu
    • , Josue A. Goss
    • , Patrick H. Campbell
    • , Grant M. Gonzalez
    • , Sung-Jin Park
    • , Andrew K. Capulli
    • , John P. Ferrier
    • , T. Fettah Kosar
    • , L. Mahadevan
    • , William T. Pu
    •  &  Kevin Kit Parker
  • Nature Biomedical Engineering | Article

    Hydrogels made from decellularized human brain tissue facilitate the direct conversion of primary mouse embryonic fibroblasts into induced neuronal cells that lead to therapeutic outcomes after transplantation in an animal model of ischaemic stroke.

    • Yoonhee Jin
    • , Jung Seung Lee
    • , Jin Kim
    • , Sungjin Min
    • , Soohyun Wi
    • , Ji Hea Yu
    • , Gyeong-Eon Chang
    • , Ann-Na Cho
    • , Yeeun Choi
    • , Da-Hee Ahn
    • , Sung-Rae Cho
    • , Eunji Cheong
    • , Yun-Gon Kim
    • , Hyong-Pyo Kim
    • , Yonghwan Kim
    • , Dong Seok Kim
    • , Hyun Woo Kim
    • , Zhejiu Quan
    • , Hoon-Chul Kang
    •  &  Seung-Woo Cho
  • Nature Biomedical Engineering | Article

    A cell-culture method involving decellularized tissue scaffolds enables the spontaneous formation of cell colonies that phenotypically recapitulate in vivo organ-specific cancer metastases.

    • Xi Tian
    • , Michael E. Werner
    • , Kyle C. Roche
    • , Ariel D. Hanson
    • , Henry P. Foote
    • , Stephanie K. Yu
    • , Samuel B. Warner
    • , Jonathan A. Copp
    • , Haydee Lara
    • , Eliane L. Wauthier
    • , Joseph M. Caster
    • , Laura E. Herring
    • , Longzhen Zhang
    • , Joel E. Tepper
    • , David S. Hsu
    • , Tian Zhang
    • , Lola M. Reid
    •  &  Andrew Z. Wang

News & Comment

  • Nature Biomedical Engineering | Editorial

    Research on disease mechanisms will increasingly be supported by progressively more sophisticated engineered tissues serving as in vitro models of human disease.

  • Nature Biomedical Engineering | News & Views

    A tissue-engineered scale model of the human ventricle made of nanofibrous scaffolds and human-stem-cell-derived cardiomyocytes enables the modelling of arrhythmia.

    • Wolfram-Hubertus Zimmermann
  • Nature Biomedical Engineering | News & Views

    A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.

    • Irina Matei
    • , Sham Rampersaud
    •  &  David Lyden
  • Nature Biomedical Engineering | News & Views

    Engineered skeletal muscle self-repairs when incorporating bone-marrow-derived macrophages, which prevent the apoptosis of resident muscle stem cells.

    • Yu Xin Wang
    •  &  Helen M. Blau
  • Nature Biomedical Engineering | News & Views

    Biopolymer matrices can modulate the transcriptomic profiles of stem-cell-derived neurons in 3D culture to make them resemble cells in specific brain regions, developmental stages and disease conditions.

    • Carsten Werner
  • Nature Biomedical Engineering | News & Views

    A tissue-decellularization method enables the culture of organ-specific metastases on a dish.

    • Jelena Urosevic
    •  &  Roger R. Gomis