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Hypertension and the Kidney

The kidneys are involved in the pathogenesis of primary hypertension and many forms of secondary hypertension, but they also represent typical targets of high blood pressure. Uncontrolled hypertension leads to structural and functional changes in the kidney, evidenced, among others, as increased albuminuria and loss of glomerular filtration rate. This group of articles covers several aspects of the bi-directional relationship between hypertension and the kidneys, including involvement of the kidneys in the pathogenesis of hypertension, evolution of hypertension-associated kidney damage, prognostic associations of BP metrics for kidney disease progression and management of BP in patients with chronic kidney disease.