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Metabolomics of ageing

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The progressive decline in physiological function with increasing age is influenced by a range of genetic and environmental factors. These factors induce transcriptomic changes that in turn alter the metabolic reactions in an organism. Large-scale metabolic phenotyping, known as metabolomics, enables the characterization of such age-associated metabolic changes, including in pathways crucial for amino acid, lipid, and carbohydrate metabolism, for redox homeostasis, and for cellular signalling.

This Collection aims to highlight research applying this powerful new tool to the study of ageing, including work identifying reliable biomarkers of physiological age or informing the development of new therapies.

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Close-up shot of a senior woman standing, with her hands folded over each other and resting on a walking stick in the foreground.

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The progressive decline in physiological function with increasing age is influenced by a range of genetic and environmental factors. These factors induce transcriptomic changes that in turn alter the metabolic reactions in an organism. Large-scale metabolic phenotyping, known as metabolomics, enables the characterization of such age-associated metabolic changes, including in pathways crucial for amino acid, lipid, and carbohydrate metabolism, for redox homeostasis, and for cellular signalling.

This Collection aims to highlight research applying this powerful new tool to the study of ageing, including work identifying reliable biomarkers of physiological age or informing the development of new therapies.

 

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