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Key issues in optimum cancer management and prevention may be greatly aided by artificial intelligence (AI), particularly deep learning and reinforcement learning methods. This AI Applied to Cancer collection, curated by Faraz Janan (Imperial College London, UK) with the assistance of Louise Wilkinson (Oxford Breast Imaging Centre, UK), provides a collection of articles and commissioned content highlighting the state-of-the-art available AI models and techniques, limitations related to the AI applications in a clinical setup, and patient perspectives and the future of AI in cancer management.