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PediaPod: PR's Podcast

Pediapod is the pediatrics podcast from Pediatric Research, produced in association with Springer Nature. Join us as we explore the etiologies of diseases of children and disorders of development, featuring interviews with top researchers and highlighted content from one of the premier journals in the field of pediatrics. Tune in here: iTunesGoogle Podcast, Overcast,  RSS Feed, and SoundCloud.

April: miRNA expression in the pediatric dilated cardiomyopathy heart

Dilated cardiomyopathy (DCM) is a rare but serious condition of children and often progresses to heart failure. The outcomes for children with DCM are poor, with 50% of pediatric patients dying or needing a heart transplant within 5 years of diagnosis. 

In this episode, Geoff Marsh meets professor Carmen Sucharov from the University of Colorado Anschutz campus and the director of the Pediatric Cardiology Research Laboratories. She and her team have been studying the regulation of micro-RNAs and their putative target genes in the pediatric DCM heart that may contribute to the distinctive phenotype of this disease in children. 

Read the article here. Listen to the PediaPod here: iTunesGoogle PodcastOvercast,  RSS Feed, and Soundcloud. (Transcript). 

 

March: The fetal immune response to maternal SARS-CoV-2 infection

Thousands of women have been infected with SARS-CoV2 during the COVID-19 pandemic. While very few of these infections have been shown to transmit vertically from mother to offspring, it remains unclear what effect, if any, a mother's SARS-CoV2 infection has on fetal development.

In this episode, we interview Dr Brian Kalish from the University of Toronto and the Hospital for Sick Children, to discuss a study he set up looking into this question by characterising the composition and cell-type specific translational landscape of umbilical cord blood mononuclear cells.

Read the study here. Listen to the PediaPod here: iTunesGoogle Podcast, Overcast,  RSS Feed, and SoundCloud.  (Transcript)

 

February: Whole-exome sequencing of epilepsy after acute symptomatic neonatal seizures

Twenty-five percent of children who survive acute symptomatic seizures as neonates go on to develop epilepsy.  Whilst there are several known risk factors, currently not enough is known about the mechanisms behind the development of epilepsy following neonatal brain injury, and thus it is not yet possible to reliably predict the individual risk of developing this disease in this group of patients.

In this episode, we speak to Adam Numis from UC San Francisco. He and his team used whole exome sequencing with targeted gene analysis to look for genetic risk factors for developing epilepsy following acute neonatal seizures, and to identify potential biological processes behind this epileptogenesis.

Read the study here. Listen to the PediaPod here: iTunesGoogle Podcast, Overcast,  RSS Feed, and SoundCloud.  (Transcript)

 

January: A new technique for estimating respiratory rates in preterm infants

Most very preterm infants experience apneas of prematurity. It is a common comorbidity of prematurity, and therefore reliable real-time monitoring of respiratory rates is key in these infants. The conventionalmethod is to use chest impedance measured with electrodes on the surface of the thorax. However, this method is known to be unreliable, as it is prone to motion artifacts. For this reason, indirect measurements such as oxygen desaturation or bradycardia are often necessary to identify apneas.

In this episode, we meet this month's featured Early Career Investigator, Dr. Kerstin Jost at the Karolinska Institute in Stockholm, Sweden. She describes a recent study of a novel technique using a commercially available nasogastric feeding tube that measures esophageal signals and uses customized software to identify the respiratory rate of non-ventilated preterm infants.

Listen to the PediaPod here: iTunesGoogle Podcast, Overcast,  RSS Feed, and SoundCloud.  (Transcript)