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Sperm biology and male reproductive health

A male factor is detected in about half of infertile couples seeking medical assistance to achieve pregnancy. A number of clinical conditions and lifestyle factors can affect male fertility through alterations to spermatogenesis, sperm function, and endocrine profiles. This Collection will gather research Articles investigating sperm functional integrity and seminal plasma molecular pathways. Submissions are also welcome that consider the physiopathology and clinical aspects of male infertility.

Submissions are welcome on a rolling basis. Find out how to submit on this page.

All articles have undergone Scientific Reports' standard peer review process and have been subject to all of the journal’s standard policies. This includes the journal’s policy on competing interests. The Guest Editor declares no competing interests with the submissions which they have handled through the peer review process. The peer review of any submissions for which the Guest Editor has competing interests is handled by another Editorial Board Member who has no competing interests.
This Collection has not been supported by sponsorship.


Sperm are unique cells, produced through the complex and precisely orchestrated process of spermatogenesis, in which there are a number of checkpoints in place to guarantee delivery of a high-quality and high-fidelity DNA product. On the other hand, reproductive pressure in males means that to produce more is, in very general terms, to perform better. Balancing quantity and quality in sperm production is thus a delicate process, subject to specific cellular and molecular control mechanisms, and sensitive to environmental conditions, that can impact fertility and offspring health. This Collection is focused on these aspects of sperm biology, as well as their impact on reproductive performance and male infertility.

Editorial | Open Access | | Scientific Reports

Testis, sperm and their environment

Biotechnologies and assisted reproduction

Clinical, experimental, and epidemiologic studies on male infertility