Collection 

Breast Cancer Awareness Month

Breast cancer is the most common cancer in women worldwide. It is a heterogeneous disease and molecular features include activation of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and/or BRCA mutations. The most critical point for the best prognosis is to identify the disease at an early-stage. Several diagnostic approaches are currently available including mammography, magnetic resonance imaging, ultrasound, computerized tomography, positron emission tomography and biopsy. Treatment strategies include surgery and radiation as well as systemic therapy approaches such as endocrine therapy for ER+ disease, chemotherapy, anti-HER2 therapy, poly(ADP-ribose) polymerase inhibitors and, more recently, immunotherapy. Adjuvant chemotherapy is also often used to prevent recurrence of the disease.

This collection, curated by the cancer team at Nature Communications on occasion of the Breast Cancer Awareness Month in October, includes a variety of both translational and clinical research articles that shed light on the complex biology of the disease and on novel diagnostic and therapeutic approaches.

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