Hydrogen atom transfer for C(sp3)-H functionalization

Hydrogen atom transfer (HAT) is a key process for the functionalization of C(sp3)-H bonds, enabling the synthesis of complex molecules from hydrocarbon chemical feedstocks. This Focus highlights innovations in technology, catalysis and methodology which seek to overcome challenges in the area.

Two molecules reacting together to form a new bond, as shown by a lightning bolt, with bubbles of hydrogen being released.


  • Thomas West

    Associate Editor, Nature Synthesis


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