Nature Outlook |

Headache

A headache can be much more than a passing annoyance. For people who experience migraines and cluster headaches, the pain and other symptoms can add up to a lifelong disability — one that the medical community has not done enough to address.

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Features and comment

The pain and other symptoms of migraines and cluster headaches can add up to a lifelong disability — one that the medical community has not done enough to address.

Outlook | | Nature

The pain, the pressure, the way it ruins your mood — everyone has experienced a headache at one time or another. But whereas most are transient and easily managed, migraines are stubborn and debilitating.

Outlook | | Nature

Monoclonal antibodies and small-molecule antagonists that target CGRP or its receptor are already having a big impact on migraine. But they have the potential to do so much more.

Outlook | | Nature

Migraines are often associated with colourful visual disturbances called auras, but many mysteries remain about how they fit into the wider biology of the syndrome.

Outlook | | Nature

A new target for migraine treatments, electrical stimulation for cluster headache, and other highlights from clinical trials and laboratory studies.

Outlook | | Nature

Sex differences in migraine prevalence have been recognized for centuries, but researchers are still just beginning to understand the factors that put women at greater risk.

Outlook | | Nature

Neurologist Alexandra Sinclair explains why intracranial hypertension is a condition of concern — on this planet and beyond.

Outlook | | Nature

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In this Review, the authors describe the evidence for abnormalities in energy metabolism and mitochondrial function in migraine, consider the potential mechanisms and highlight treatments that affect metabolism. They conclude that migraine is a conserved adaptive response that helps to restore brain energy homeostasis.

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Migraine is prevalent in the paediatric population and represents a major cause of disability. This Review outlines the epidemiology and natural history of paediatric migraine, discusses the recent landmark clinical trials of treatments for paediatric migraine and examines the best evidence-based interventions for this population in light of these new findings.

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Cluster headache is characterized by unilateral headaches associated with ipsilateral autonomic features, such as lacrimation and rhinorrhoea. This Primer by May et al. discusses the pathophysiology, diagnosis and management of cluster headache in addition to the quality-of-life issues faced by patients.

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