Advances in organic synthesis

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Making organic molecules can have rich benefits for our everyday lives by enabling the discovery and preparation of pharmaceutical drugs or the synthesis of catalysts for a range of industrial processes. As a result, developing practical methods to synthesize organic molecules is the main focus of organic chemists. Improving efficiency in terms of the number of steps and/or the yields of these steps, or developing more sustainable methods involving green reagents, catalysts or solvents or a reduced energy requirement are typically ways to make synthetic routes more attractive. Such routes are likely to be adopted by chemists in academia and industry, who are working towards producing target molecules. This Collection will serve to bring together articles describing advances in organic synthesis for use in these settings.

We welcome submissions to the Collection on topics including, but not limited to, transition-metal catalysis, organocatalysis, asymmetric catalysis, natural product synthesis, biosynthesis, as well as photochemical and electrochemical methods in synthesis. The Collection will additionally focus on technologies that enable efficient or sustainable approaches to organic synthesis, such as high-throughput synthesis, flow synthesis or automated synthesis.

For some articles, it may be that the target molecules represent the advance in the work, and for others it may be the method of reaching these wherein the main advance lies. The Collection will include articles that fit into either of these categories, as well as those cases where both the target molecules and the method represent an improvement over the state-of-the-art.

The Collection primarily welcomes original research papers. All submissions will be subject to the same peer review process and editorial processes as regular Nature Synthesis, Nature Communications and Communications Chemistry articles.

Robotic arms producing a chemical reaction by using laboratory tubes filled with colored liquids among the levitating models of organic molecules

Enabling Technologies

Synthesis and use of rings

Metal-catalyzed processes

Transition-metal-free synthesis