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Single-cell omics – techniques and applications

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As single cell sequencing technologies started coming of age, we are increasingly better placed to probe the heterogeneity of multicellular biological system. These techniques over the last decade have shed light on developmental processes, cancer etiology, plant biology, and more. This Collection will focus on further methodological advances in the area of single cell sequencing and single cell omics, as well as on the applications of these new techniques to gain further insights into biological processes.

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Editors

  • Elin Gray

    Edith Cowan University, Australia

  • Yao Lu  &

    Yao Lu

    Chinese Academy of Sciences, China

  • Philipp Thomas

    Imperial College London, UK

Elin Gray is an Associate Professor at the School of Medical and Health Sciences at Edith Cowan University. Dr Gray's current research aims to identify blood biomarkers for diagnosis and prognosis of melanoma and other cancers to guide treatment decisions. Her team utilises and develops novel liquid biopsies including single cell analysis of circulating tumour cells. In addition, she is interested in identifying intratumoral determinants of proliferation and drug resistance towards the developing better treatment strategies. Dr Gray has been an Editorial Board Member for Scientific Reports since 2019.

 

 

Yao Lu is a Professor and group leader of the single-cell analysis laboratory at Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS). He received his Ph.D. in analytical chemistry from the same institute in 2010. After conducting postdoctoral training at the biomedical engineering department of Yale University from 2010 to 2015, he joined the faculty of DICP in September of 2015. His current research focuses on developing microfluidics-based single-cell secretion analysis technologies for precision diagnostics and medicine. Prof Lu has been an Editorial Board Member for Scientific Reports since 2019.

 

 

Philipp Thomas is a Senior Lecturer in the Department of Mathematics at Imperial College London. His research focuses on understanding single-cell dynamics and their implications for cellular heterogeneity. Dr Thomas’ research group uses an interdisciplinary approach combining stochastic modelling, statistical inference and data analysis of single-cell data. He is a UKRI Future Leaders Fellow and has previously held a fellowship of the Royal Commission for the Exhibition of 1851. Dr Thomas has been an Editorial Board Member for Scientific Reports since 2019.