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In this Collection Modern Pathology's Editor-in-Chief, Dr. George Netto, has selected some of the most cited papers published in 2020. In an associated podcast, available here, Dr Netto reflects on the topics of these papers, and briefly discusses five selected studies involving COVID-19, DICER1, NTRK, Precursor lesions of HPV-Independent Vulvar Squamous Cell Carcinoma, and Applications of Computational Pathology and Artificial Intelligence in Pathology.