van Dijk et al. discuss the potential for antimicrobial resistance as a consequence of disinfectant use. The authors advocate for the prudent use of disinfectants in all sectors of society.
Reviews and Commentary
cfr and fexA genes in methicillin-resistant Staphylococcus aureus from humans and livestock in the Netherlands
Schouls et al. characterize antimicrobial resistance genes in MRSA isolates from humans and livestock in the Netherlands. The multidrug resistance gene cfr and the phenicol resistance gene fexA are identified in both types of samples, including in samples taken from persons having professional contact with livestock.
Antibiotic-resistant organisms establish reservoirs in new hospital built environments and are related to patient blood infection isolates
Sukhum, Newcomer et al. evaluate reservoirs of antibiotic-resistant organisms within the built environment and patient samples from an established and a newly-built intensive care unit. The authors demonstrate colonization of sink drains and other sites and show relatedness between environmental reservoirs and patient infections.
A prospective matched case-control study on the genomic epidemiology of colistin-resistant Enterobacterales from Dutch patients
Vendrik et al performed a prospective matched case-control study on the genomic epidemiology of colistin-resistant Escherichia coli and Klebsiella pneumoniae from Dutch patients. Colistin resistance is present, but uncommon in the Netherlands and caused by the mcr gene in a minority of colistin-resistant isolates.
Corbin et al. train machine learning models on electronic health record data to predict susceptibility of infections to particular antibiotics (personalized antibiograms). Antibiotic selection driven by personalized antibiograms achieves similar coverage rates to those seen in actual clinical practice using fewer broad spectrum antibiotics.