Collection |

Gut-brain axis

  • Nature Neuroscience | Article

    In this study, the authors show that host microbiota play a key role in modulating microglia homeostasis. Germ-free mice or mice with only limited microbiota complexity displayed defects in microglial cell proportions and maturation, leading to impaired innate immune responses. The authors find that short-chain fatty acid signaling regulates these effects in vivo.

    • Daniel Erny
    • , Anna Lena Hrabě de Angelis
    • , Diego Jaitin
    • , Peter Wieghofer
    • , Ori Staszewski
    • , Eyal David
    • , Hadas Keren-Shaul
    • , Tanel Mahlakoiv
    • , Kristin Jakobshagen
    • , Thorsten Buch
    • , Vera Schwierzeck
    • , Olaf Utermöhlen
    • , Eunyoung Chun
    • , Wendy S Garrett
    • , Kathy D McCoy
    • , Andreas Diefenbach
    • , Peter Staeheli
    • , Bärbel Stecher
    • , Ido Amit
    •  &  Marco Prinz
  • Nature Medicine | Article

    Alterations in the gut microbiota affect stroke outcomes via modulation of T cells, suggesting a gut-brain axis linking commensal microbes with the CNS.

    • Corinne Benakis
    • , David Brea
    • , Silvia Caballero
    • , Giuseppe Faraco
    • , Jamie Moore
    • , Michelle Murphy
    • , Giulia Sita
    • , Gianfranco Racchumi
    • , Lilan Ling
    • , Eric G Pamer
    • , Costantino Iadecola
    •  &  Josef Anrather
  • Nature | Article

    Increased acetate production by an altered gut microbiota in rats fed a high-fat diet activates the parasympathetic nervous system, which in turn promotes increased insulin secretion, increased food intake, obesity and related changes.

    • Rachel J. Perry
    • , Liang Peng
    • , Natasha A. Barry
    • , Gary W. Cline
    • , Dongyan Zhang
    • , Rebecca L. Cardone
    • , Kitt Falk Petersen
    • , Richard G. Kibbey
    • , Andrew L. Goodman
    •  &  Gerald I. Shulman
  • Nature Reviews Gastroenterology & Hepatology | Review Article

    Bidirectional gut–brain communications are proving key to both gastrointestinal and neurological diseases. This Review explores the role of the mucosal immune system as gatekeeper and master regulator of these brain–gut and gut–brain communications.

    • Nick Powell
    • , Marjorie M. Walker
    •  &  Nicholas J. Talley
  • Nature Immunology | Review Article

    Magarian Blander and colleagues review the effects of the microbiome on innate and adaptive immunological players and how microbiota-derived bioactive molecules affect inflammation and the host response to infection, vaccination and cancer.

    • J Magarian Blander
    • , Randy S Longman
    • , Iliyan D Iliev
    • , Gregory F Sonnenberg
    •  &  David Artis
  • Nature Reviews Gastroenterology & Hepatology | Review Article

    The enteric nervous system is vital for life, and its dysfunction participates not only in digestive disorders, but also in diseases of the central nervous system (CNS). Here, Rao and Gershon discuss the gastrointestinal consequences of neurological disorders, the acquisition of CNS disease in the gut and the spread of pathology along the gut–brain axis.

    • Meenakshi Rao
    •  &  Michael D. Gershon
  • Nature Reviews Neurology | Review Article

    Increasing evidence suggests that Alzheimer disease (AD) is not simply a CNS disorder, but involves interactions between systemic and brain-related factors. Wang and colleagues review the role of amyloid-β (Aβ) in AD, highlighting systemic abnormalities linked to Aβ metabolism and discussing how these abnormalities might influence central pathways of Aβ production and clearance.

    • Jun Wang
    • , Ben J. Gu
    • , Colin L. Masters
    •  &  Yan-Jiang Wang
  • Nature Reviews Urology | Review Article

    Functional urological disorders, like their gastrointestinal counterparts, are interrelated and characterized by a chronic course and treatment resistance. Poor outcomes might be attributable to underlying psychological and psychiatric disorders, as the co-occurrence of functional disorders with mood and anxiety disorders is common. In this Review, the authors describe the hypothetical bladder–gut–brain axis, and explain how it is a useful framework under which this interaction can be studied.

    • Carsten Leue
    • , Joanna Kruimel
    • , Desiree Vrijens
    • , Adrian Masclee
    • , Jim van Os
    •  &  Gommert van Koeveringe
  • Nature Microbiology | Perspective

    In this Perspective, Suez and Elinav describe the potential for therapeutic approaches based on the use of metabolites secreted, modulated or degraded by the gut microbiome, and issues that will be critical for their implementation.

    • Jotham Suez
    •  &  Eran Elinav
  • Nature Reviews Endocrinology | Review Article

    Here, Patrice Cani and colleagues discuss interactions between gut microorganisms, the endocannabinoid system and host metabolism, in the context of both physiology and pathophysiology. The authors highlight the importance of gut barrier function by discussing the role of specific factors involved in intestinal permeability and their role in the gut microbiota–endocannabinoid system axis. The therapeutic potential of targeting the endocannabinoid system to treat cardiometabolic disorders and intestinal inflammation is also discussed.

    • Patrice D. Cani
    • , Hubert Plovier
    • , Matthias Van Hul
    • , Lucie Geurts
    • , Nathalie M. Delzenne
    • , Céline Druart
    •  &  Amandine Everard
  • Nature Reviews Disease Primers | Primer

    Functional dyspepsia is a functional gastrointestinal disorder characterized by discomfort or pain in the upper abdomen (generally associated with food intake) with no apparent underlying organic cause. The three subtypes of functional dyspepsia are postprandial distress syndrome, epigastric pain syndrome and a subtype with mixed features.

    • Paul Enck
    • , Fernando Azpiroz
    • , Guy Boeckxstaens
    • , Sigrid Elsenbruch
    • , Christine Feinle-Bisset
    • , Gerald Holtmann
    • , Jeffrey M. Lackner
    • , Jukka Ronkainen
    • , Michael Schemann
    • , Andreas Stengel
    • , Jan Tack
    • , Stephan Zipfel
    •  &  Nicholas J. Talley