In this supplement

Despite global efforts to improve access to treatment, existing HIV/AIDS therapies are still not reaching the majority of those in need. This Nature collection draws together recent molecular and cellular studies on the interplay between HIV and the immune system, which are helping to advance the search for an effective vaccine and new drugs to combat the HIV/AIDS epidemic.


Current Research

Structure of an unliganded simian immunodeficiency virus gp120 core

Bing Chen, Erik M. Vogan, Haiyun Gong, John J. Skehel, Don C. Wiley and Stephen C. Harrison

Nature 433, 834–841 (2005). doi:10.1038/nature03327

Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells Free access

Ya-Lin Chiu, Vanessa B. Soros, Jason F. Kreisberg, Kim Stopak, Wes Yonemoto and Warner C. Greene

Nature 435, 108–114 (2005). doi:10.1038/nature03493

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

Joseph J. Mattapallil, Daniel C. Douek, Brenna Hill, Yoshiaki Nishimura, Malcolm Martin and Mario Roederer

Nature 434, 1093–1097 (2007). doi:10.1038/nature03501

Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells

Qingsheng Li et al.

Nature 434, 1148–1152 (2005). doi:10.1038/nature03513

The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity

Jean-Marc Jacque and Mario Stevenson

Nature 441, 641–645 (2006). doi:10.1038/nature04682

Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

Diane M. Roberts et al.

Nature 441, 239–243 (2006). doi:10.1038/nature04721

Distribution and three-dimensional structure of AIDS virus envelope spikes

Ping Zhu et al.

Nature 441, 847–852 (2006). doi:10.1038/nature04817

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Cheryl L. Day et al.

Nature 443, 350–354 (2006). doi:10.1038/nature05115

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Tongqing Zhou et al.

Nature 445, 732–737 (2007). doi:10.1038/nature05580