Vascular
biology
Vol. 407, No. 6801 (14 September 2000).
|
PDF(132K)
|
 |
Research in vascular biology has boomed in recent years. The advances made have led to significant insights into the treatment not only of pulmonary vascular diseases such as atherosclerosis, ischaemic and congenital heart disorders, stroke, thrombosis and hypertension, but also diabetes and tumour development. But cardiovascular diseases remain a major cause of mortality worldwide, regardless of the recent advances in medical and surgical treatment. Indeed, as life expectancy in the developed world increases, cardiovascular conditions affecting the elderly are also likely to rise. And this escalation in cardiovascular disorders may not be confined to the developed world as recent data suggest that heart disease is also increasing among Asians and Chinese. As we are catapulted into the genomics era, exciting new therapeutic avenues are uncovered which may eventually lead to the tailoring of therapies to a patient's specific metabolic and genetic profile. To accelerate progress into the medical treatment of these disorders we must start by expanding our knowledge in the basic regulatory mechanisms underlying vascular biology. With this view in mind, this month's Nature Insight aims to reveal the current research developments that are relevant to the understanding of the complex nature of vascular biology.
Nature has been revered in publishing many key studies in the field of vascular biology, we hope that you will find this collection of reviews enlightening and inspiring.
Andrea Kauffmann-Zeh
Senior Editor
 | |||
 | |||
| A
genetic blueprint for cardiac development DEEPAK SRIVASTAVA AND ERIC N. OLSON
| 221 | | |
| |||
| Genomic
circuits and the integrative biology of cardiac diseases KENNETH R. CHIEN
| 227 | | |
| |||
 | |||
| Atherosclerosis
ALDONS J. LUSIS
| 233 | | |
| |||
| |||
| Vascular-specific
growth factors and blood vessel formation GEORGE D. YANCOPOULOS, SAMUEL DAVIS, NICHOLAS W. GALE, JOHN S. RUDGE, STANLEY J. WIEGAND & JOCELYN HOLASH
| 242 | | |
| |||
| |||
| Angiogenesis
in cancer and other diseases PETER CARMELIET AND RAKESH K. JAIN
| 249 | | |
| |||
| |||
| Thrombin
signalling and protease-activated receptors SHAUN R. COUGHLIN
| 258 | | |
| |||
| Perspectives
for vascular genomics EDWARD M. RUBIN AND ALAN TALL
| 265 | | |
| |||
 | |||
| Vascular
biology: a route to novel cardiovascular drugs ASTRAZENECA
| 270 | | |
Nature
© Macmillan Publishers Ltd 1999 Registered No. 785998 England. 
