Editor's choice: organoids

A limitation of in vitro research has been lack of physiological context; cells typically being looked at in uniform culture. Advances in our understanding of stem-cell development, however, have given researchers tools for generating 3D cell-culture that self-organises into organ-resembling organoids. As organoid technology has improved we have seen a dramatic expansion in its application, providing insights on a range of tissues – both healthy and diseased – as well as in drug development, and organ transplantation. 

Slice of a cerebral organoid in a petri dish

Organoids as a model for basic biology

Organoid based treatment screening

Patient derived organoids

Advancing organoid culture techniques