Ovarian Cancer Awareness Month

Ovarian cancer is one of the most common gynecologic cancers. It is typically diagnosed at a late stage and has no effective screening strategy. Late diagnosis, tumour heterogeneity and the development of chemoresistance contribute to the poor patient survival. One of the most important risk factors for ovarian cancer is a genetic factor, in particular mutations of BRCA1 and BRCA2. Standard treatment for ovarian cancer is surgery followed by platinum-based chemotherapy. In recurrent cancer, chemotherapy, anti-angiogenic agents and poly(ADP-ribose) polymerase inhibitors are used, and immunological therapies are currently being tested.

On the occasion of Ovarian Cancer Awareness Month in September, here is a collection curated by the cancer team at Nature Communications of the latest research on this disease, including a comment piece about how the cell of origin influences ovarian cancer biology, metastasis and response to treatment.

ovarian tube

Section 1

Section 2