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Extracellular vesicles in cell biology and medicine

Extracellular vesicles (EVs) are cell-derived membranous structures which act as intercellular communicators in both physiological and pathological situations, hence offering extraordinary opportunities for clinical applications. This Collection delivers an overview of current advances in EV research, their application in therapeutics and diagnostics, and advances in the methodological tools for EV study.


All articles have undergone Scientific Reports' standard peer review process and have been subject to all of the journal’s standard policies. This includes the journal’s policy on competing interests. The Guest Editor declares no competing interests with the submissions which they have handled through the peer review process. The peer review of any submissions for which the Guest Editor has competing interests is handled by another Editorial Board Member who has no competing interests.
This Collection has not been supported by sponsorship.


Extracellular vesicles (EVs) represent a new paradigm, both in cell biology and medicine; specifically, the idea that functional content itself may be delivered directly to cells. EVs are cell-derived membranous structures that work as intercellular communicators exerting their function by transporting their cargo that includes nucleic acids, proteins and lipids. EVs play an essential role in normal physiology, but also in pathological communication, for instance, in cancer, EVs are thought to deliver oncogenic molecules (such as proteins, peptides, RNAs…) to neighboring cells, enhancing propagation of neoplastic cells. Not surprisingly, EV research has become common-place in every field of biomedicine, being explored as diagnostics and therapeutics.

This Collection gathers original Articles that investigate the application of extracellular vesicles on diagnostics and therapeutics, and that report advances in the knowledge of EV biology and the methodological tools for their study.

Editorial | Open Access | | Scientific Reports

Extracellular vesicles in disease

Extracellular vesicles’ biology and endogenous function

Tools and methods for studying Extracellular Vesicles