Magnetic Resonance Imaging (MRI) is a crucial diagnostic tool within modern healthcare, yet its availability remains largely confined to high-income nations. The imperative to extend MRI accessibility to lower-income countries aligns with the pursuit of universal health coverage, a key target of the UN’s Sustainable Development Goal 3. In an interview with Nature Communications, three scientists dedicated to advancing MRI accessibility in Africa share their insights. These experts include Dr Udunna Anazodo (Assistant Professor at McGill University, Canada and Scientific Director, Medical Artificial Intelligence (MAI) Lab, Lagos, Nigeria), Dr Johnes Obungoloch (Lecturer at Mbarara University of Science and Technology, Uganda) and Dr Ugumba Kwikima (Neuroradiologist, Lugalo General Military Hospital, Tanzania). Our discussion considers the current MRI landscape across African countries and the associated challenges and opportunities. We also cover technological innovations making a difference, such as low field MRI, alongside the role of advocacy initiatives in bolstering accessibility. We finally look ahead to the future of MRI in Africa.