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Over recent years Vitamin D has grown from being just a bone vitamin to a multi-tasking vitamin that can play a key part in many systems. This special issue of the European Journal of Clinical Nutrition curated by Associate Editor Dr Giovanna Muscogiuri aims to evaluate aspects of Vitamin D research that are important to clinical and public health nutrition, and demonstrate how Vitamin D supplementation could be useful in the prevention and treatment of extra-skeletal diseases.